Definition of and mechanism for opioid-induced sedation.
Definition of and mechanism for opioid-induced sedation.
复制标题
DOI：
10.1053/jpmn.2001.25012
复制
发表时间：
2001-09
期刊：
影响因子：
--
通讯作者：
S. Young-McCaughan;C. Miaskowski
中科院分区：
文献类型：
--
作者：
S. Young-McCaughan;C. Miaskowski
尽管镇静作用被认为是阿片类镇痛药最常见的副作用之一，但这种现象的机制和特征仍然难以捉摸，而且该领域的研究极其有限。本报告将关于阿片类药物作用机制的研究结果与关于意识现象的研究结果相结合，建立了一个阿片类药物如何在中枢神经系统中产生镇静作用的模型。基于这种整合，提出了阿片类药物诱导的镇静作用的定义，以鼓励对这一令人困惑且具有临床重要性的现象进行探讨和研究。
Although sedation is acknowledged to be one of the most common side effects of opioid analgesics, the mechanisms and characteristics of this phenomenon remain elusive, and research in this area is extremely limited. This report integrates research findings on the mechanism of action of opioids with research findings on the phenomenon of consciousness to develop a model of how opioids may act in the central nervous system to produce sedation. Based on this integration, a definition of opioid-induced sedation is proposed to encourage dialogue and research on this perplexing and clinically significant phenomenon.