Distribution of neuronal nicotinic acetylcholine receptor gene restriction fragment length polymorphisms in inbred and partially inbred mice.
Distribution of neuronal nicotinic acetylcholine receptor gene restriction fragment length polymorphisms in inbred and partially inbred mice.
复制标题
近交和部分近交小鼠神经元烟碱乙酰胆碱受体基因限制性片段长度多态性的分布。
DOI：
10.1097/00008571-199510000-00009
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Boyd,RT
中科院分区：
文献类型：
--
作者：
Nagavarapu,U;Boyd,RT
Nicotine is a powerful pharmacological agent producing addiction, behavioural changes, and enhancement of cognitive function in some cases. The use of nicotine via cigarette smoking is widespread in society today. A large part of smoking behaviour is designed to regulate the smoker's level of nicotine. For example, pretreatment with mecamylamine, an antagonist of nicotine, causes an increase in smoking activity (Stolerman et al., 1973; Pomerleau et al., 1987). Genetic differences in the response to nicotine may play a part in smoking behaviour as well as in the development of tolerance to and dependence on nicotine. Inbred animals have been used to study the genetic component of drug and alcohol related behaviours (reviewed in Crabbe et al., 1994). Some gene loci affecting drug responses have been characterized. Several quantitative trait loci (QTL) affecting responses to ethanol have been localized in the genome including a region on the mouse chromosome 9 near to the nicotinic acetylcholine receptor (nAChR) genes o 3, o 5, and ß4, and the dopamine D, receptor (DRD2) gene (Crabbe et al., 1994). A specific DRD2 allele in some studies has been associated with alcoholism (Noble, 1993). More recent work showed an association between a specific DRD2 allele and smoking behaviour (Noble, 1994). Common genetic factors may influence the effects of nicotine and alcohol. Alcoholics are often heavy smokers and consumption of alcohol increases smoking behaviour. Extensive studies using inbred
