Relationship of Urinary cGMP Excretion with Aging and Menopausal Status in a General Population
Relationship of Urinary cGMP Excretion with Aging and Menopausal Status in a General Population
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DOI：
10.5551/jat.no083
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发表时间：
2009-01-01
影响因子：
4.4
通讯作者：
Shimamoto, Takashi
中科院分区：
文献类型：
--
作者：
Cui, Renzhe;Iso, Hiroyasu;Shimamoto, Takashi
目的：老龄化和绝经后妇女患心血管疾病的风险增加；然而，关于衰老和绝经与血管生物活性关系的流行病学证据有限。方法：我们调查了1,541名年龄在40-79岁的日本男性和女性的尿环鸟苷(CGMP)排泄量与年龄和绝经的关系。用I-125标记的cGMP放射免疫法测定24小时尿cGMP排泄量，并调整尿肌酐排泄量(nmoL/mmolcreatinine)。结果：男性和女性的年龄与尿cGMP排泄量呈正相关。经年龄和其他心血管危险因素调整后，绝经后妇女尿cGMP排泄量显著低于绝经前妇女：48.3+/-0.04nmol/mmovs.61.5+/-0.07nmo1/mmolp=0.006。结论：绝经后妇女cGMP相关的血管扩张功能受损。
Aim: Aging and postmenopausal women are associated with increased risks of cardiovascular disease; however, epidemiological evidence concerning the relationship of aging and the menopause with vascular biological activity is limited.Methods: We investigated the relationship of aging and the menopause with urinary excretion of cyclic guanosine 3',5' monophosphate (cGMP) in 1,541 Japanese men and women aged 40 to 79 years. The 24-hour urinary excretion of cGMP was measured with a I-125-labeled cGMP radioimmunoassay and was adjusted for urinary creatinine excretion (nmol/mmol creatinine).Results: Aging was positively associated with urinary excretion of cGMP for both sexes. Postmenopausal women excreted significantly less urinary cGMP than premenopausal women after adjustment for age and other cardiovascular risk factors: 48.3 +/- 0.04 nmol/mmol vs. 61.5 +/- 0.07 nmol/mmol, p=0.006.Conclusions: Our data suggest that cGMP-related vasodilatation is impaired in postmenopausal women.