Creatine kinase activity in amyotrophic lateral sclerosis patients
Creatine kinase activity in amyotrophic lateral sclerosis patients
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DOI：
10.1007/s10072-003-0158-3
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发表时间：
2003-11-01
影响因子：
3.3
通讯作者：
Stelmasiak, Z
中科院分区：
文献类型：
--
作者：
Ilzecka, J;Stelmasiak, Z
本研究旨在探讨肌萎缩侧索硬化症(ALS)患者血清肌酸激酶(CK)的变化。以前的研究表明ALS患者CK活性升高，这已被认为是患者生存的一个指标。这项研究是在卢布林大学医学院神经病学系进行的。30名ALS患者参与了这项研究。平均病程17个月。用N-乙酰半胱氨酸酶法测定血清CK水平。43.3%的ALS患者CK升高。ALS患者的血清CK水平在不同年龄、性别、病程或临床状况的ALS患者之间没有显著差异。肢体ALS患者血清CK水平显著高于球部ALS患者。本研究证实ALS患者血清CK活性升高。CK活性取决于ALS的肢体发作或延髓发作，而不取决于疾病的持续时间和临床情况的严重程度。
The aim of this study was to investigate creatine kinase (CK) in the serum of amyotrophic lateral sclerosis (ALS) patients. Previous investigations have shown an increased CK activity in ALS patients and this has been suggested to be an indicator of patients survival. The study was conducted at the Department of Neurology, University School of Medicine in Lublin. Thirty ALS patients took part in the study. The average duration of the disease was 17 months. Serum CK levels were measured by the enzymatic method with N-acethylcysteine. CK was elevated in 43.3% of the ALS patients. There were no significant differences in the serum CK level between the groups of the ALS patients depending on age, sex, duration of the disease, or clinical condition of patients. The CK level was significantly higher in the serum of the patients with a limb onset than in patients with a bulbar onset of ALS. Our study confirmed the increase in the serum CK activity in ALS patients. CK activity depends on a limb onset or a bulbar onset of ALS, but not on the duration of the disease and the severity of the clinical condition.