ONTOGENY OF CIRCADIAN RHYTHMICITY FOR MELATONIN, SEROTONIN, AND N-ACETYLSEROTONIN IN HUMANS
ONTOGENY OF CIRCADIAN RHYTHMICITY FOR MELATONIN, SEROTONIN, AND N-ACETYLSEROTONIN IN HUMANS
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DOI：
10.1111/j.1600-079x.1986.tb00747.x
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发表时间：
1986-01-01
影响因子：
10.3
通讯作者：
GUPTA, D
中科院分区：
文献类型：
--
作者：
ATTANASIO, A;RAGER, K;GUPTA, D
采用放射免疫法测定28例1周~9个月婴儿血清褪黑素、5-羟色胺和N-乙酰5-羟色胺浓度。分别于1200h和2400h取血标本。出生后立即出现血清5-羟色胺的昼夜差异。从第一个月龄到第三到第九个月龄，血清5-羟色胺浓度在1200h和2400h显著降低(P<；0.001)。昼夜N-乙酰5-羟色胺浓度的显著差异(P<；0.05)首先出现在1-3个月龄。血清褪黑素浓度虽然可以检测到，但在出生时没有显示出任何昼夜差异。褪黑激素浓度在3个月龄前逐渐升高，此后出现显著的昼夜差异(P<；0.01)。结果表明，在人类中，5-羟色胺的昼夜节律在出生时就已经存在，褪黑激素的昼夜节律在出生后发展。
The serum concentration of melatonin, serotonin, and N-acetylserotonin were measured by RIA procedures in 28 infants aged 1 week to 9 months. Blood specimens were obtained at 1200 hr and 2400 hr. A day-night difference in serum serotonin was present immediately after birth. A significant (P < 0.001) decrease in serum serotonin concentrations at 1200 hr and 2400 hr was observed from the first month of age to the third to ninth month of age. A significant (P < 0.05) difference in day-night N-acetylserotonin concentration is first seen at age 1-3 months. Serum melatonin concentrations, though detectable, did not show any day-night difference at birth. Melatonin concentrations progressively increased up to the third month of age, and a significant (P < 0.01) day-night difference appeared thereafter. The results indicate that in humans the circadian organization for serotonin already exists at birth, and the circadian melatonin rhythm develops after birth.