THE CELL-SURFACE RECEPTORS FOR INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA ARE IDENTICAL
THE CELL-SURFACE RECEPTORS FOR INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA ARE IDENTICAL
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DOI：
10.1038/324266a0
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发表时间：
1986-11-20
期刊：
影响因子：
64.8
通讯作者：
URDAL, DL
中科院分区：
文献类型：
--
作者：
DOWER, SK;KRONHEIM, SR;URDAL, DL
白介素1(IL-1)是一种可诱导小鼠T淋巴细胞1、2增殖的因子，可引起多种生物反应。这些症状包括骨吸收、成纤维细胞增殖、肝细胞急性时相蛋白释放、软骨破坏和发热。这种活性光谱与IL-1作为炎症介质的作用是一致的。最近的序列数据显示，IL-1家族中至少有两个成员，它们被命名为IL-1α和IL-1β8-11。我们先前发现，小鼠T细胞和成纤维细胞都具有相对分子质量(MR)∼80,000(80K)的人IL-1β12，13的质膜受体。我们在这里表明，IL-1α的受体与IL-1β的受体是相同的。这一结果提出了一个问题，即IL-1α和IL-1β的生物学活性之间可能存在什么分离(如果有的话)。
Interleukin-1 (IL-1) is a factor that can induce proliferation of murine T lymphocytes1,2and can elicit a variety of other biological responses. These include bone resorption3, fibroblast proliferation4, acute phase protein release from hepatocytes5, cartilage breakdown6and fever7. This spectrum of activities is consistent with a role for IL-1 as a mediator of inflammation. Recently, sequence data have shown that there are at least two members of the IL-1 family; these distantly related proteins have been termed IL-1αand IL-1β8–11. We have found previously that both murine T cells and fibroblasts possess a relative molecular mass (Mr) ∼80,000 (80K) plasma membrane receptor for human IL-1β12,13. We show here that the receptor for IL-1αon both murine and human cells is identical to that for IL-1β. This result raises the issue of what separation, if any, there might be between the biological activities of IL-1αand IL-1β.