Predictors of heartburn during sleep in a large prospective cohort study
Predictors of heartburn during sleep in a large prospective cohort study
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DOI：
10.1378/chest.127.5.1658
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发表时间：
2005-05-01
期刊：
影响因子：
9.6
通讯作者：
Iber, C
中科院分区：
文献类型：
--
作者：
Fass, R;Quan, SF;Iber, C
背景和目标。夜间胃食管反流可能导致夜间胃灼热，已被证明与更严重的胃食管反流病（GERD）有关。本研究的目的是在一项大型前瞻性队列研究中确定睡眠期间胃灼热的临床预测因素。方法：研究对象是睡眠心脏健康研究 (SHHS) 招募参与者的父母队列的成员。 SHHS 是一项多中心、纵向、队列研究，研究睡眠呼吸障碍对心血管的影响。作为招募过程的一部分，家长队列成员完成了一份调查问卷，以评估美国九个社区家长队列中睡眠期间胃灼热与患者人口统计数据、睡眠异常、病史和社交习惯之间的关系。所有变量（p < 0.05 水平显着）均作为自变量纳入多变量逻辑回归模型中，睡眠状态期间胃灼热作为因变量结果：共有 15,314 名受试者完成了有关睡眠期间胃灼热的问题，其中 3,806 名受试者 (24.9%) 报告有这种症状。在四个日益全面的多变量模型中，体重指数（BMI）增加、碳酸软饮料摄入量、打鼾和白天嗜睡（Epworth 嗜睡量表评分）、失眠、高血压、哮喘和苯二氮卓类药物的使用是睡眠期间胃灼热的强烈预测因素。相比之下，大学教育降低了报告睡眠期间胃灼热的风险。结论：睡眠期间胃灼热在普通人群中非常常见。据报道，此类胃食管反流病症状与体重指数增加、碳酸软饮料摄入量、打鼾和白天嗜睡、失眠、高血压、哮喘和苯二氮卓类药物的使用密切相关。总体而言，睡眠期间胃灼热可能与睡眠问题和白天过度嗜睡有关。
Background and aims. Nocturnal gastroesophageal reflux, which may result in nocturnal heartburn, has been demonstrated to be associated with a more severe form of gastroesophageal reflux disease (GERD). The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study.Methods: Study subjects were members of the parent cohorts from which the Sleep Heart Health Study (SHHS) recruited participants. SHHS is a multicenter, longitudinal, cohort study of the cardiovascular consequences of sleep-disordered breathing. As part of the recruitment process, parent cohort members completed a questionnaire that permitted an assessment of the relationships between heartburn during sleep, and patient demographics, sleep abnormalities, medical history, and social habits in nine community-based parent cohorts across the United States. All variables, significant at the p < 0.05 level, were included as independent variables in multivariate logistic regression models with heartburn during sleep status included as the dependent variableResults: A total of 15,314 subjects completed the questions about heartburn during sleep, and of these, 3,806 subjects (24.9%) reported having this symptom. In four increasingly comprehensive multivariate models, increased body mass index (BMI), carbonated soft drink consumption, snoring and daytime sleepiness (Epworth sleepiness scale score), insomnia, hypertension, asthma, and usage of benzodiazepines were strong predictors of heartburn during sleep. in contrast, college education decreased the risk of reporting heartburn during sleep.Conclusions: Heartburn during sleep is very common in the general population. Reports of this type of symptom of GERD are strongly associated with increased BMI, carbonated soft drink consumption, snoring and daytime sleepiness, insomnia, hypertension, asthma, and usage of benzodiazepines. Overall, heartburn during sleep may be associated with sleep complaints and excessive daytime sleepiness.