The use of thiazides in the prevention of renal calculi.
The use of thiazides in the prevention of renal calculi.
复制标题
使用噻嗪类药物预防肾结石。
DOI：
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发表时间：
1970
影响因子：
14.6
通讯作者：
D. A. García
中科院分区：
文献类型：
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作者：
E. Yendt;G. Guay;D. A. García
氢氯噻嗪的疗效，在一个通常的剂量为50毫克。在67例复发性钙结石患者中评价了每日两次预防进一步结石形成的作用。其中53例患者有特发性高钙尿症（11例伴有尿路感染），1例有髓质海绵肾和尿路感染，2例仅有尿路感染; 11例患者未检测到结石形成的原因。如果存在尿路感染，也进行治疗。治疗开始时，33名患者（第1组）无结石，34名患者（第2组）有尿路结石。在第1组中，从结石症状发作到开始噻嗪类药物治疗共343患者年（py），共发生194次（0.57/py），包括83例结石自发排出和30例大手术，但在72 py治疗期间，仅发生2次（0.03/py），均导致结石自发排出。第2组的34例患者在噻嗪治疗前的343年期间有365次发作（1.1/py），但在治疗的64年期间只有34次发作（0.53/py）。第2组患者的许多发作与既往结石有关，其中只有4例患者有明确的新结石形成证据。副作用，通常是轻微的，经历了25名患者，在三名患者因副作用而停止治疗。
The efficacy of hydrochlorothiazide, in a usual dosage of 50 mg. twice daily, in preventing further stone formation was evaluated in 67 patients with recurrent calcium stones. Fifty-three of these patients had idiopathic hypercalciuria (11 with associated urinary infection), one had medullary sponge kidneys and urinary infection, and two had urinary infection only; no cause for stone formation was detected in 11 patients. Urinary infection was also treated when present. Thirty-three patients (Group 1) were stone-free and 34 patients (Group 2) had stones in the urinary tract when treatment was started. In Group 1 during a total of 343 patient years (py) between the onset of stone symptoms and the institution of thiazide therapy there were 194 episodes (.57 per py) including 83 stones passed spontaneously and 30 major operations, but during 72 py on treatment there were only two episodes (.03 per py), both of which resulted in spontaneous passage of stones. The 34 patients in Group 2 had 365 episodes (1.1 per py) during the 343 py before thiazide therapy but only 34 episodes (.53 per py) during the 64 py on treatment. Many episodes in the Group 2 patients were related to previous stones, and in only four of these patients was there clear-cut evidence of new stone formation. Side effects, usually mild, were experienced by 25 patients; in three patients treatment was discontinued because of side effects.