The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models
The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models
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DOI：
10.1098/rstb.2006.1861
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发表时间：
2006-07-29
影响因子：
6.3
通讯作者：
Cone, Roger D.
中科院分区：
文献类型：
--
作者：
Ellacott, Kate L. J.;Cone, Roger D.
十多年前，这种口服液的分子基础在很大程度上是未知的。当时，许多实验室都在试图克隆编码肥胖、糖尿病、脂肪、胖子和刺鼠基因的基因，希望这些肥胖基因的识别将有助于揭示能量稳态、食欲和能量消耗的过程。肥胖症和糖尿病的特征分别阐明了脂肪激素瘦素及其受体的性质，而刺鼠基因的克隆最终导致了瘦素调节摄入和支出的关键神经系统之一的鉴定和特征。在这篇综述中，我们描述了被称为中枢黑素皮质素系统的神经回路，并讨论了目前对其在摄食和其他涉及能量平衡的过程中所起作用的理解。
A little more than a decade ago, the molecular basis of the lipostat was largely unknown. At that time, many laboratories were at work attempting to clone the genes encoding the obesity, diabetes, fatty, tubby and agouti loci, with the hope that identification of these obesity genes would help shed light on the process of energy homeostasis, appetite and energy expenditure. Characterization of obesity and diabetes elucidated the nature of the adipostatic hormone leptin and its receptor, respectively, while cloning of the agouti gene eventually led to the identification and characterization of one of the key neural systems upon which leptin acts to regulate intake and expenditure. In this review, we describe the neural circuitry known as the central melanocortin system and discuss the current understanding of its role in feeding and other processes involved in energy homeostasis.