SAFETY OF ORAL INTAKE OF VITAMIN-E
SAFETY OF ORAL INTAKE OF VITAMIN-E
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DOI：
10.1093/ajcn/48.3.612
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发表时间：
1988-09-01
影响因子：
7.1
通讯作者：
MACHLIN, LJ
中科院分区：
文献类型：
--
作者：
BENDICH, A;MACHLIN, LJ
关于口服维生素E安全性的文献综述表明，维生素E的毒性很低。补充维生素E对血清脂质和脂蛋白水平的影响不一致。动物研究表明，维生素E不会致突变、致癌或致畸。在采用双盲方案的人体研究和大规模人群研究中，即使剂量高达3200mg /d (3200iu /d)，口服维生素E补充剂也几乎没有副作用。
A review of the literature concerning the safety of oral intake of vitamin E indicated that the toxicity of vitamin E is low. Vitamin E supplementation has resulted in inconsistent effects in serum lipid and lipoprotein levels. Animal studies showed that vitamin E is not mutagenic, carcinogenic, or teratogenic. In human studies with double-blind protocols and in large population studies, oral vitamin E supplementation resulted in few side effects even at doses as high as 3200 mg/d (3200 IU/d).