Prevalence and determinants of elevated high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy
Prevalence and determinants of elevated high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy
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DOI：
10.1016/j.jjcc.2013.07.008
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Jalali, Arash
中科院分区：
文献类型：
--
作者：
Jenab, Yaser;Pourjafari, Marzieh;Jalali, Arash
背景资料：本研究旨在评估肥厚型心肌病（HCM）患者高敏心肌肌钙蛋白T（hs-cTnT）升高作为心脏损伤标志物的患病率及其决定因素。（71.4%男性;平均年龄51.18 ± 15.47岁）通过测量血清hs-cTnT水平沿着其他临床评估进行评价。有42例（42.9%）患者的最低血清hs-cTnT水平为14 ng/L。平均hs-cTnT水平为12.37 ng/L（6.94-24.26 ng/L）。两组在胸痛纽约心脏协会心功能分级、体表心电图左室肥厚、24小时动态心电图非持续性室性心动过速、左房面积指数、二尖瓣口舒张早期充盈速度与舒张早期充盈速度比值方面差异有显著性（Ea间隔）在二尖瓣间隔环水平（E/Ea间隔），最大左心室（LV）壁厚>= 30 mm，hs-cTnT < 14 ng/L与hs-cTnT ≥ 14 ng/L患者超声心动图左室流出道峰值跨瓣压差>= 30 mmHg。然而，经过多因素分析，年龄，最大左室壁厚度，LA面积指数，和E/Ea间隔仍然是独立的决定因素hs-cTnT升高HCM.Conclusions：结果表明，hs-cTnT升高，在我们的HCM患者的显着数量，因此，hs-cTnT可以作为一个有价值的标记物，在HCM患者心肌损伤。(C)2013年日本心脏病学院。由爱思唯尔有限公司出版。保留所有权利。
Background: This study was designed to evaluate the prevalence and determinants of increased high-sensitivity cardiac troponin T (hs-cTnT) as a marker of cardiac injury in patients with hypertrophic cardiomyopathy (HCM).Methods: A total of 98 consecutive patients with HCM (71.4% males; mean age 51.18 +/- 15.47 years) between 2012 and 2013 were evaluated by measuring the level of serum hs-cTnT along with other clinical assessments.Results: There were 42(42.9%) patients with a minimum serum hs-cTnT level of 14 ng/L. The mean hs-cTnT level was 12.37 ng/L (6.94-24.26 ng/L). There were significant differences in chest pain New York Heart Association functional class, left ventricular hypertrophy in the surface electrocardiogram, non-sustained ventricular tachycardia in 24-h electrocardiogram-Holter monitoring, left atrial (LA) area index, ratio of peak early (E) transmitral filling velocity to peak early diastolic annular velocity (Ea septal) at the level of the septal mitral annulus (E/Ea septal), maximum left ventricular (LV) wall thickness >= 30 mm, and peak LV outflow gradient >= 30 mmHg in echocardiography between the patients with hs-cTnT < 14 ng/L and those with hs-cTnT >= 14 ng/L. However, after multivariate analysis, age, maximum LV wall thickness, LA area index, and E/Ea septal remained as the independent determinants of elevated hs-cTnT in HCM.Conclusions: The results demonstrated that hs-cTnT was elevated in a significant number of our HCM patients; therefore, hs-cTnT can be introduced as a valuable marker of myocardial injury in HCM patients. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.