Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
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DOI:
10.1152/physiol.00002.2010
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发表时间:
2010-10
期刊:
影响因子:
--
通讯作者:
Kobilka BK
中科院分区:
文献类型:
--
作者:
Deupi X;Kobilka BK
G protein coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiologic responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.
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