Respiratory symptoms and pulmonary function in an elderly nonsmoking population
Respiratory symptoms and pulmonary function in an elderly nonsmoking population
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DOI：
10.1378/chest.115.1.49
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发表时间：
1999-01-01
期刊：
影响因子：
9.6
通讯作者：
McDonnell, WF
中科院分区：
文献类型：
--
作者：
Berglund, DJ;Abbey, DE;McDonnell, WF
目的：通过肺功能测试（PFT）检测老年非吸烟者慢性气道疾病（CAD）的危险因素，并将报告的呼吸道症状与PFT测量结果相关联。设计：观察性调查。设置：加州的几个社区。测量：通过标准化问卷评估暴露和呼吸史，进行PFT并推导预测方程。结果：在多元逻辑回归中，PFT阻塞的重要危险因素包括报告的环境烟草烟雾（ETS）暴露（相对风险[RR] = [RR] = 1.44），父母CAD或海湾热（RR = 1.47）、儿童呼吸道疾病史（RR = 2.15）、年龄增长、男性海。过去吸烟的次数具有临界意义（吸烟10年的RR = 1.29;有明确症状的CAD患者PFT阻塞的发生率为24.9%，而无CAD症状的患者为7.5%。哮喘患者PFT阻塞的发生率为36.0%，肺气肿患者为70.6%。此外，通过协方差分析，症状性CAD与肺功能降低相关。经协变量校正后，有明确CAD症状者FEV预测值的平均百分比为90.6%，而无症状者为97.8%（p < 0.001）。结论：年龄、ses、父母病史、儿童呼吸系统疾病和ETS暴露是PFT显示梗阻的重要危险因素。自我报告的呼吸道症状也与PFT显著相关。
Objective: To examine risk factors for chronic airway disease (CAD) in elderly nonsmokers, as determined by pulmonary function tests (PFTs), and to correlate reported respiratory symptoms with PFT measures.Design: An observational survey.Setting: Several communities in California.Measurements: Exposures and respiratory history were assessed by standardized questionnaire, PFTs were performed and prediction equations derived.Results: Significant risk factors for obstruction on PFTs in multiple logistic regression included reported environmental tobacco smoke (ETS) exposure (relative risk [RR] = [RR] = 1.44), parental CAD or bay fever (RR = 1.47), history of childhood respiratory illness (RR = 2.15), increasing age, and male sea. The number of rears of past smoking was of borderline significance (RR = 1.29 for 10 years of smoking; p = 0.66), The prevalence of obstruction on PFTs was 24.9% in those with definite symptomatic CAD, compared with 7.5% in those with no symptoms of CAD, The prevalence of obstruction was 36.0% among those crith asthma and 70.6% among those with emphysema, Also, symptomatic CAD correlated with reduction in lung function by analysis of covariance. The mean percent predicted FEV, adjusted for covariates was 90.6% in persons with definite symptoms of CAD, compared with 97.8% in those without it (p < 0.001).Conclusions: Age, ses, parental history, childhood respiratory illness, and reported ETS exposures were significant risk factors for obstruction on PFTs. Self-reported respiratory symptoms also correlated significantly with PFTs.