Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken
Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken
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DOI：
10.1016/j.clon.2019.04.001
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发表时间：
2019-07-01
影响因子：
3.4
通讯作者：
Limoli, C. L.
中科院分区：
文献类型：
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作者：
Vozenin, M-C;Hendry, J. H.;Limoli, C. L.
FLASH放射治疗（FLASH- rt）是一项可以改变未来放射治疗方式的技术。这项技术涉及放疗的超快递送，其剂量率比常规临床实践中使用的剂量率高几个数量级。与传统剂量率放疗相比，这种极短的暴露时间导致对暴露于FLASH-RT的正常组织的相对保护的惊人观察。在这里，我们总结了目前关于FLASH效应的知识，并综合了在各种实验动物模型（小鼠、斑马鱼、猪、猫）、各种器官（肺、肠、脑、皮肤）和不同小组40年研究中报告的观察结果。我们还提出了FLASH效应的可能机制，以及临床应用的可能途径。(C) 2019皇家放射科医师学院。Elsevier Ltd.出版。版权所有。
FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently used in routine clinical practice. This very short time of exposure leads to the striking observation of relative protection of normal tissues that are exposed to FLASH-RT as compared with conventional dose rate radiotherapy. Here we summarise the current knowledge about the FLASH effect and provide a synthesis of the observations that have been reported on various experimental animal models (mice, zebrafish, pig, cats), various organs (lung, gut, brain, skin) and by various groups across 40 years of research. We also propose possible mechanisms for the FLASH effect, as well as possible paths for clinical application. (C) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.