Adherence to secondary stroke prevention strategies - Results from the German stroke data bank
Adherence to secondary stroke prevention strategies - Results from the German stroke data bank
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DOI：
10.1159/000069490
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发表时间：
2003-01-01
影响因子：
2.9
通讯作者：
Diener, HC
中科院分区：
文献类型：
--
作者：
Hamann, GF;Weimar, C;Diener, HC
只有非常有限的数据可获得关于患者坚持使用旨在防止中风复发的抗血栓药物。依从性和依从性的降低可能会显著影响任何中风预防策略的效果。这项来自大型中风数据库的研究提供了有关中风患者坚持他们推荐的预防性药物的比率的代表性数据。从1998年1月1日开始的两年时间里，23个神经内科的所有急性中风或短暂性脑缺血发作患者都被纳入了德国中风数据库。数据在一个中央数据管理单位进行前瞻性收集、审查、验证和处理。只有12个随访率在80%或更高的中心被纳入此次评估。3420例患者在3个月后获得随访，2640例患者在卒中后一年获得随访。一年后，96%的报告患者仍然坚持至少一种医学中风预防策略。在出院时接受阿司匹林治疗的患者中，92.6%的患者在3个月后和84%的患者在一年后报告使用该药物，而氯吡格雷的这两个数字分别为81.6%和61.6%，口服抗凝药物的这两个数字分别为85.2%和77.4%。大多数更换药物的患者从阿司匹林转向氯吡格雷。在这项观察性研究的条件下，坚持中风预防策略是非常好的。阿司匹林和口服抗凝药物的粘附率最高。一年后，很少有患者停止服用中风预防药物。版权所有(C)2003 S.Karger AG，巴塞尔。
Only very limited data are available concerning patient adherence to antithrombotic medication intended to prevent a recurrent stroke. Reduced adherence and compliance could significantly influence the effects of any stroke prevention strategies. This study from a large stroke data bank provides representative data concerning the rate of stroke victims adhering to their recommended preventive medication. During a 2-year period beginning January 1, 1998, all patients with acute stroke or TIA in 23 neurological departments with an acute stroke unit were included in the German Stroke Data Bank. Data were collected prospectively, reviewed, validated and processed in a central data management unit. Only 12 centers with a follow-up rate of 80% or higher were included in this evaluation. 3,420 patients were followed up after 3 months, and 2,640 patients were followed up one year after their stroke. After one year, 96% of all patients reported still adhere to at least one medical stroke prevention strategy. Of the patients receiving aspirin at discharge, 92.6% reported to use that medication after 3 months and 84% after one year, while 81.6 and 61.6% were the respective figures for clopidogrel, and 85.2 and 77.4% for oral anticoagulation. Most patients who changed medication switched from aspirin to clopidogrel. Under the conditions of this observational study, adherence to stroke prevention strategies is excellent. The highest adherence rate is noticed for aspirin and oral anticoagulation. After one year, very few patients stopped taking stroke preventive medication. Copyright (C) 2003 S. Karger AG, Basel.