REGRESSIVE EVENTS IN NEUROGENESIS
REGRESSIVE EVENTS IN NEUROGENESIS
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DOI：
10.1126/science.6474175
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
STANFIELD, BB
中科院分区：
文献类型：
--
作者：
COWAN, WM;FAWCETT, JW;STANFIELD, BB
脊椎动物神经系统的大部分区域的发育包括神经元变性的明显阶段，在此期间，最初产生的神经元的相当大的比例死亡。这种退化主要是调整每个神经元群体的大小，以适应其投射野的大小或功能需求，但在这个过程中，它似乎也消除了许多神经元，这些神经元的轴突已经生长到错误的目标或目标区域内的不适当区域。此外，许多最初形成的连接后来被消除，而不会导致母细胞死亡。在大多数情况下，这种过程的消除导致终端轴突分支的去除，因此作为一种机制，以“微调”神经元布线。然而，现在也有几个例子表明，由于长轴突侧支的选择性变性，早期形成的通路被大规模消除。因此，这些退化现象远不是神经发育中相对次要的方面，现在被认为在决定成熟神经系统的形式方面起着重要作用。
The development of most regions of the vertebrate nervous system includes a distinct phase of neuronal degeneration during which a substantial proportion of the neurons initially generated die. This degeneration primarily adjusts the magnitude of each neuronal population to the size or functional needs of its projection field, but in the process it seems also to eliminate many neurons whose axons have grown to either the wrong target or an inappropriate region within the target area. In addition, many connections that are initially formed are later eliminated without the death of the parent cell. In most cases such process elimination results in the removal of terminal axonal branches and hence serves as a mechanism to "fine-tune" neuronal wiring. However, there are now also several examples of the large-scale elimination of early-formed pathways as a result of the selective degeneration of long axon collaterals. Thus, far from being relatively minor aspects of neural development, these regressive phenomena are now recognized as playing a major role in determining the form of the mature nervous system.