Synthesis and Characterization of PLA-PEG Biocomposite Incorporated with Sol-Gel Derived 45S5 Bioactive Glass
Synthesis and Characterization of PLA-PEG Biocomposite Incorporated with Sol-Gel Derived 45S5 Bioactive Glass
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溶胶-凝胶衍生的 45S5 生物活性玻璃的 PLA-PEG 生物复合材料的合成和表征
DOI：
10.1016/j.matpr.2019.06.466
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
A. Nur Syazana
中科院分区：
文献类型：
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作者：
N. S. N. S. Aliaa;M. N. Fazliah;S. Fatimah;A. Nur Syazana
环境友好和生物相容性材料对生物医学应用做出了重大贡献。本文采用溶胶-凝胶法制备了聚乳酸（PLA）、聚乙二醇（PEG）和45 S5生物活性玻璃（BG）复合材料。傅里叶变换红外（FTIR）光谱显示BG-聚合物复合物的受控的不同透射率范围，这表明改善的可溶解性并且在复合物内没有发生明显的化学相互作用。聚合物共混物的场发射扫描电子显微镜（FESEM）图像显示存在可见的凹槽/空隙，尽管在掺入BG后看不到凹槽/空隙，这解释了BG-聚合物复合材料的自催化降解速率的降低。然而，复合材料中的空隙会降低拉伸试验验证的整体强度。BG加入到聚合物共混物复合材料中，通过降低自催化降解速率，显示出更好的可持续结构，这可能为组织工程应用提供更好的复合材料生物活性。
Environmental friendly and biocompatible materials contribute significantly towards biomedical applications. The current study showcases composites comprising of polylactic acid (PLA), polyethylene glycols (PEG) and sol-gel derived 45S5 bioactive glass (BG) fabricatedviasolvent casting technique. Fourier transform infrared (FTIR) spectra shows a controlled different range of transmittance of BG-polymer composite which indicates improved miscibility and no distinct chemical interactions occurring within the composites. Field Emission Scanning Electron Microscopy (FESEM) image of polymer blend shows the presence of visible grooves/voids, although none can be seen after incorporation of BG, which explains the decreasing of auto-catalytic degradation rate of the BG-polymer composite. However, voids creation within the composites decrease the overall strength verifiedviatensile test. BG incorporated in polymer blend composite shows a better sustaining structure by decreasing the auto-catalytic degradation rate which may provide better bioactivity of the composite for tissue engineering application.