The sweet and sour of serological glycoprotein tumor biomarker quantification.
The sweet and sour of serological glycoprotein tumor biomarker quantification.
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DOI：
10.1186/1741-7015-11-31
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发表时间：
2013-02-07
期刊：
影响因子：
9.3
通讯作者：
Diamandis EP
中科院分区：
文献类型：
--
作者：
Kuzmanov U;Kosanam H;Diamandis EP
Aberrant and dysregulated protein glycosylation is a well-established event in the process of oncogenesis and cancer progression. Years of study on the glycobiology of cancer have been focused on the development of clinically viable diagnostic applications of this knowledge. However, for a number of reasons, there has been only sparse and varied success. The causes of this range from technical to biological issues that arise when studying protein glycosylation and attempting to apply it to practical applications. This review focuses on the pitfalls, advances, and future directions to be taken in the development of clinically applicable quantitative assays using glycan moieties from serum-based proteins as analytes. Topics covered include the development and progress of applications of lectins, mass spectrometry, and other technologies towards this purpose. Slowly but surely, novel applications of established and development of new technologies will eventually provide us with the tools to reach the ultimate goal of quantification of the full scope of heterogeneity associated with the glycosylation of biomarker candidate glycoproteins in a clinically applicable fashion.
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DOI：
10.1080/15257770802257903
发表时间：
2008-08
期刊：
Nucleosides, nucleotides & nucleic acids
影响因子：
--
作者：
Boese BJ;Corbino K;Breaker RR
通讯作者：
Breaker RR
影响因子：
7.4
作者：
Alley, William R., Jr.;Madera, Milan;Mechref, Yehia;Novotny, Milos V.
通讯作者：
Novotny, Milos V.
影响因子：
7.4
作者：
Ahn, Yeong Hee;Kim, Yong-Sam;Yoo, Jong Shin
通讯作者：
Yoo, Jong Shin
影响因子：
4.4
作者：
Anderson, NL;Anderson, NG;Pearson, TW
通讯作者：
Pearson, TW
影响因子：
4.4
作者：
Arnold, James N.;Saldova, Radka;Rudd, Pauline M.
通讯作者：
Rudd, Pauline M.