Low-grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes
Low-grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes
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DOI：
10.1111/j.1365-2796.2004.01350.x
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发表时间：
2004-08-01
影响因子：
11.1
通讯作者：
Taskinen, MR
中科院分区：
文献类型：
--
作者：
Leinonen, ES;Hiukka, A;Taskinen, MR
目标。本研究的目的是评估 2 型糖尿病中炎症、内皮激活和早期动脉粥样硬化之间的关系。横断面研究。设置和主题。我们在一个研究中心研究了 239 名 2 型糖尿病患者 [71 名患有临床心血管疾病 (CVD)] 和 78 名年龄 50-75 岁的健康对照受试者。方法。颈动脉内膜中层厚度（IMT）通过超声测定。测量循环细胞内粘附分子-1、血管细胞粘附分子-1、E-选择素、超敏 C 反应蛋白、人血清淀粉样蛋白 A、白介素-6、单核细胞集落刺激因子、IIA 型分泌型非胰腺磷脂酶 A(2)、葡萄糖、HbA1c 和脂质/脂蛋白变量。 结果。在整个年龄范围内，糖尿病患者的颈动脉 IMT 明显比健康对照者厚。患有CVD的糖尿病患者的IMT也比没有CVD的患者更厚，但在控制混杂因素后这种差异消失了。糖尿病患者中除 IL-6 外的炎症和内皮标志物的浓度显着高于健康对照，但在患有和不患有 CVD 的糖尿病患者中具有可比性。糖尿病患者IMT的主要决定因素是血压、年龄和糖尿病病程。结论。糖尿病患者的低度炎症和内皮细胞活化增加，但与 IMT 或临床 CVD 无关。炎症反应似乎是代谢综合征的一个特征，而不是动脉粥样硬化的直接决定因素。
Objectives. The objective of this study was to assess the relationship between inflammation, endothelial activation and incipient atherosclerosis in type 2 diabetes.Design. Cross-sectional study.Setting and subjects. We studied 239 type 2 diabetic patients [71 with clinical cardiovascular disease (CVD)] and 78 healthy control subjects, aged 50-75 in a single research centre.Methods. Carotid intima-media thickness (IMT) was determined by ultrasound. Circulating intracellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, ultra-sensitive C-reactive protein, human serum amyloid A, interleukin-6, monocyte colony-stimulating factor, secretory nonpancreatic phospholipase A(2) type IIA, glucose, HbA1c, and lipid/lipoprotein variables were measured.Results. Carotid IMT was significantly thicker in diabetic patients than healthy controls across the whole age range. IMT was also thicker in diabetic patients with, than without, CVD, but this difference disappeared after controlling for confounding factors. Concentrations of the inflammatory and endothelial markers except IL-6 were significantly higher in the diabetic patients than in healthy controls, but comparable in diabetic patients with and without CVD. The main determinants of IMT in the diabetic patients were blood pressure, age and diabetes duration.Conclusions. Low-grade inflammation and endothelial activation are increased in diabetic patients but do not associate with IMT or clinical CVD. The inflammatory reaction seems to be rather a feature of the metabolic syndrome than a direct determinant of atherosclerosis.