Model of the transient neurovascular response based on prompt arterial dilation.
Model of the transient neurovascular response based on prompt arterial dilation.
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基于即时动脉扩张的短暂神经血管反应模型。
DOI：
10.1038/jcbfm.2013.90
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ress,David
中科院分区：
文献类型：
--
作者：
Kim,JungHwan;Khan,Reswanul;Thompson,JeffreyK;Ress,David
短暂的神经刺激会导致血管和代谢反应的典型模式，这是流行的脑成像方法（如功能性磁共振成像）的基础。然而，暂态氧转运及其与脑血流量（CBF）和氧代谢（cro2）耦合的机制尚不清楚。最近的实验表明，短暂的刺激会引起动脉血管扩张，而不是静脉血管扩张。这项工作提供了一个基于一维对流-扩散传输的瞬态动脉效应的短暂刺激的神经血管反应模型。血红蛋白氧解离包括在内，使绝对氧浓度的预测。动脉CBF反应使用集总线性血流模型建模，cmro2反应使用伽马函数建模。使用6个参数，该模型成功拟合了猫大脑皮层短暂视觉刺激所获得的161/166测量血管外氧时间过程。结果显示CBF和cmoo2反应如何相互竞争以产生观察到的血流动力学反应特征：初始下降、高氧峰值、低冲和环形。预测的CBF和cmo_2响应幅值与实验测量值一致。该模型为定量解释大脑中的氧运输提供了一个强有力的框架；特别是，它的血管内氧浓度预测为功能磁共振成像反应提供了一个新的模型。
Brief neural stimulation results in a stereotypical pattern of vascular and metabolic response that is the basis for popular brain-imaging methods such as functional magnetic resonance imagine. However, the mechanisms of transient oxygen transport and its coupling to cerebral blood flow (CBF) and oxygen metabolism (CMRO2) are poorly understood. Recent experiments show that brief stimulation produces prompt arterial vasodilation rather than venous vasodilation. This work provides a neurovascular response model for brief stimulation based on transient arterial effects using one-dimensional convection-diffusion transport. Hemoglobin oxygen dissociation is included to enable predictions of absolute oxygen concentrations. Arterial CBF response is modeled using a lumped linear flow model, and CMRO2response is modeled using a gamma function. Using six parameters, the model successfully fit 161/166 measured extravascular oxygen time courses obtained for brief visual stimulation in cat cerebral cortex. Results show how CBF and CMRO2responses compete to produce the observed features of the hemodynamic response: initial dip, hyperoxic peak, undershoot, and ringing. Predicted CBF and CMRO2response amplitudes are consistent with experimental measurements. This model provides a powerful framework to quantitatively interpret oxygen transport in the brain; in particular, its intravascular oxygen concentration predictions provide a new model for fMRI responses.