Pir-B inhibits the DC function and disturbs the Th17/Treg balance in lung cancer murine model.
Pir-B inhibits the DC function and disturbs the Th17/Treg balance in lung cancer murine model.
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Pir-B在肺癌小鼠模型中抑制DC功能并扰乱Th17/Treg平衡
DOI：
10.18632/oncotarget.21763
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发表时间：
2017-12-29
期刊：
影响因子：
--
通讯作者：
Wang K
中科院分区：
文献类型：
--
作者：
Wu H;Zheng X;Dong L;Li C;Zhang M;Wang G;Wang K
成对免疫球蛋白样受体B（Pir-B）是一种表达于树突状细胞（DCs）表面的抑制性受体。Pir-B抑制Th 1反应，诱导Th 2细胞分化，导致Th 1/Th 2细胞失衡。然而，Pir-B在肺癌小鼠模型中对Th 17/调节性T细胞（TclB）平衡的作用和潜在机制仍在很大程度上未知。在本研究中，DC功能和Th 17/Treg平衡在肺癌的进展过程中被破坏，这伴随着Pir-B表达的增加。在体外用Pir-B siRNA转染或施用IL-6后，Th 17细胞的降低的反应得以恢复，而增强的TcB分化减弱。此外，体内转移Pir-B沉默的DC或注射IL-6增加了Th 17应答并降低了Treg分化。我们的研究表明，Pir-B在肺癌的发展过程中通过IL-6途径抑制DC功能并扰乱Th 17/Treg平衡，有助于抑制抗肿瘤免疫。
Paired immunoglobulin-like receptor B (Pir-B) was an inhibitory receptor expressed on the surfaces of dendritic cells (DCs). Pir-B inhibit T helper (Th) 1 response and induce Th2 cell differentiation, leading to the imbalance of Th1/Th2 cells. However, the role and potential mechanism of Pir-B on the balance of Th17/regulatory T cells (Tregs) is still largely unknown in lung cancer murine model. In the present study, the DC function and Th17/Treg balance were destroyed during the progression of lung cancer and this was accompanied by an increased expression of Pir-B. After transfection with Pir-B siRNA or administration of IL-6 in vitro, the decreased response of Th17 cells were restored, whereas the augmented differentiation of Tregs was diminished. Further, the transfer of Pir-B silenced DCs or the injection of IL-6 in vivo increased Th17 response and decreased Treg differentiation. Our study has demonstrated that Pir-B inhibits the DC function and disturbs the Th17/Treg balance via IL-6 pathway during the progression of lung cancer, contributing to inhibited antitumor immunity.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
30.5
作者：
Manel, Nicolas;Unutmaz, Derya;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
3.7
作者：
Wang L;Lin J;Zhou Z;Huo R;Shen B;Sun Y;Li N
通讯作者：
Li N
影响因子：
2.7
作者：
Li, Jian-Guo;Du, Yu-Mo;Ran, Pi-Xin
通讯作者：
Ran, Pi-Xin
DOI：
10.3779/j.issn.1009-3419.2013.12.08
发表时间：
2013-12
期刊：
Zhongguo fei ai za zhi = Chinese journal of lung cancer
影响因子：
--
作者：
Zhi X
通讯作者：
Zhi X