Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs
Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs
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DOI：
10.1016/j.modgep.2005.06.009
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发表时间：
2006-01-01
影响因子：
1.2
通讯作者：
Yasugi, S
中科院分区：
文献类型：
--
作者：
Hojo, M;Takada, I;Yasugi, S
过氧化物酶体增殖物激活受体（Peroxisome proliferator-activated receptor，PPARs）在多种器官和组织中的脂质代谢、稳态、细胞分化和增殖等生物学现象中起着重要作用。然而，它们在消化器官发育中的功能尚未得到研究，尽管人们认为它们参与了消化器官肿瘤的发生和消退。为了给分析PPARs在鸡胚消化器官发育中的功能提供基础数据，我们对从早期发育阶段到孵化后阶段的食管、腺胃（腺胃）、肌胃（肌胃）、小肠和大肠中PPARa、β（δ）和γ的表达进行了全面的分析。结果表明，各过氧化物酶体增殖物激活受体的表达均具有时空调控性。一般而言，过氧化物酶体增殖物激活受体β广泛表达于消化器官，而过氧化物酶体增殖物激活受体α和γ表达有限。在肠道中，所有PPARs在孵化后表达，表明它们在成体肠道的生理学中起重要作用。(C)2005年由Elsevier B. V.出版
Peroxisome proliferator-activated receptors (PPARs) play very important roles in various biological phenomena such as regulation of lipid metabolism, homeostasis, cell differentiation and proliferation, in a variety of organs and tissues. However, their functions in the development of the digestive organs have not been studied yet, although it has been supposed that they are involved in the tumor development and regression of digestive organs. To provide fundamental data to analyze functions of PPARs in the developing digestive organs in the chicken embryos, we performed thorough analysis of expression of PPAR alpha, beta (delta) and gamma in the esophagus, proventriculus (glandular stomach), gizzard (muscular stomach), small and large intestines from early developmental stages to post hatch stages. The results showed that each PPAR is expressed in spatio-temporally regulated manner. In general, PPAR beta is widely expressed among digestive organs whereas PPAR alpha and gamma showed restricted expression. In the intestine, all PPARs are expressed after hatch, indicating that they play important roles in the physiology of the adult intestine. (C) 2005 Published by Elsevier B.V.