Safety and tolerability of ultrasound-guided synovial needle biopsy in Japanese arthritis patients
Safety and tolerability of ultrasound-guided synovial needle biopsy in Japanese arthritis patients
复制标题
日本关节炎患者超声引导滑膜针活检的安全性和耐受性
DOI：
10.1080/14397595.2020.1847754
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发表时间：
2020
影响因子：
2.2
通讯作者：
近藤 泰
中科院分区：
文献类型：
--
作者：
Yoko Miura;Hirotsugu Ohkubo;Akio Niimi;and Satoshi Kanazawa.;近藤 泰
ObjectivesWe寻求澄清的安全性和耐受性的超声（US）引导下的滑膜针穿刺活检在手和膝关节在Japanese arthritis patients.MethodsA共9个连续的关节炎患者被招募和安排美国引导下的滑膜针穿刺活检。患者完成了安全性调查问卷和活检前后关节疼痛、僵硬和肿胀的患者报告结局（PRO）数据。我们还记录了患者的特征和愿意接受第二次活检相同的技术。所有滑膜穿刺活检样本进行了评估，病理和微生物检查，以验证是否临床evaluations.ResultsFive和4例患者进行了US引导下的手和膝关节活检，分别。PRO数据显示活检前后疼痛、肿胀或僵硬水平无显著差异，平均每次手术采集11.8个样本。未报告严重并发症，包括关节感染、出血或血管迷走神经体征。在83个（78%）样本中确定了组织学上足够的滑膜组织。我们能够提交活检样本的病理和细菌分析，以排除脓毒性arthritis.ConclusionWe表明，微创US引导下穿刺活检是一种安全和耐受性良好的程序，收集的滑膜组织是足够的质量进行病理分析。
ObjectivesWe sought to clarify the safety and tolerability of ultrasound (US)-guided synovial needle biopsy in hand and knee joints in Japanese arthritis patients.MethodsA total of nine consecutive arthritis patients were recruited and scheduled for US-guided synovial needle biopsies. Patients completed a safety questionnaire and patient-reported outcomes (PRO) data of joint pain, stiffness, and swelling pre- and postbiopsy. We also recorded patients’ characteristics and willingness to undergo a second biopsy by the same technique. All synovial needle biopsy samples were assessed with pathological and microbial examination to verify whether clinical evaluation was possible.ResultsFive and 4 patients underwent US-guided biopsy from hand and knee joints, respectively. PRO data showed no significant differences in pain, swelling, or stiffness levels before and after biopsy, with a mean 11.8 samples collected per procedure. No significant complications, including joint infection, bleeding, or vasovagal signs, were reported. Histologically adequate synovial tissue was identified in 83 (78%) samples. We were able to submit the biopsy samples to pathological and bacterial analysis to exclude septic arthritis.ConclusionWe demonstrated that a minimally invasive US-guided needle biopsy is a safe and well-tolerated procedure and the synovial tissue collected was of adequate quality for pathological analysis.
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