Recent perspectives in ocular drug delivery.
Recent perspectives in ocular drug delivery.
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DOI：
10.1007/s11095-008-9694-0
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发表时间：
2009-05
影响因子：
3.7
通讯作者：
Mitra AK
中科院分区：
文献类型：
--
作者：
Gaudana R;Jwala J;Boddu SH;Mitra AK
眼睛的解剖学和生理学使其成为一个高度受保护的器官。设计一种有效的眼科疾病的治疗方法，尤其是眼后节的治疗，一直被认为是一项艰巨的任务。局部和玻璃体内给药途径的局限性迫使科学家寻找替代给药方式，如眼周给药途径。转运体靶向给药因其能克服当前治疗中的许多障碍而引起了该领域的极大兴趣。纳米技术在治疗一系列疾病方面的应用一直非常有前途。本文简要介绍了微乳、纳米混悬液、纳米粒、脂质体、脂质体、树枝状大分子、植入物和水凝胶等眼部给药系统。本文还介绍了眼部基因治疗的潜力。在不久的将来，前段和后段眼病的非侵入性缓释药物的研究将受到极大的关注。更好地了解眼部疾病的本质、障碍和影响体内表现的因素，将极大地推动新给药系统的发展。目前发明新的药物输送系统的势头有望大大改进治疗危及视力的疾病的疗法。
Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective therapy for ocular diseases, especially for the posterior segment, has been considered as a formidable task. Limitations of topical and intravitreal route of administration have challenged scientists to find alternative mode of administration like periocular routes. Transporter targeted drug delivery has generated a great deal of interest in the field because of its potential to overcome many barriers associated with current therapy. Application of nanotechnology has been very promising in the treatment of a gamut of diseases. In this review, we have briefly discussed several ocular drug delivery systems such as microemulsions, nanosuspensions, nanoparticles, liposomes, niosomes, dendrimers, implants, and hydrogels. Potential for ocular gene therapy has also been described in this article. In near future, a great deal of attention will be paid to develop non-invasive sustained drug release for both anterior and posterior segment eye disorders. A better understanding of nature of ocular diseases, barriers and factors affecting in vivo performance, would greatly drive the development of new delivery systems. Current momentum in the invention of new drug delivery systems hold a promise towards much improved therapies for the treatment of vision threatening disorders.