Oxidized LDL and expression of monocyte adhesion molecules
Oxidized LDL and expression of monocyte adhesion molecules
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DOI：
10.1016/s0168-8227(99)00041-8
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发表时间：
1999-09-01
影响因子：
5.1
通讯作者：
Yokode, M
中科院分区：
文献类型：
--
作者：
Kita, T;Kume, N;Yokode, M
动脉内膜局部区域大量单核细胞/巨噬细胞以及活化的 T 淋巴细胞的积累似乎是动脉粥样硬化形成的标志。我们的报告表明，溶血磷脂酰胆碱 (lyso-PC) 是一种极性磷脂成分，在致动脉粥样硬化脂蛋白（例如糖尿病和 III 型高脂血症患者的氧化 LDL 和残余脂蛋白）中增加，可以上调单核细胞和 T 淋巴细胞的粘附分子以及生长因子（例如肝素结合表皮生长因子样生长因子和 PDGF-A 和 B 链）。最近我们发现了氧化 LDL 的新型受体，命名为 Lox-1。因此：在本文中，我们总结了氧化LDL与其受体LOX-I之间相互作用在动脉粥样硬化早期阶段的重要性。 (C) 1999 Elsevier Science Ireland Ltd. 保留所有权利。
Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore: in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-I in terms of early stage of atherogenesis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.