Prospective study of snoring and risk of hypertension in women.
Prospective study of snoring and risk of hypertension in women.
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DOI：
10.1093/oxfordjournals.aje.a010085
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发表时间：
1999-10
影响因子：
5
通讯作者：
F. Hu;W. Willett;G. Colditz;A. Ascherio;F. Speizer;Bernard A. Rosner;C. Hennekens;M. Stampfer
中科院分区：
文献类型：
--
作者：
F. Hu;W. Willett;G. Colditz;A. Ascherio;F. Speizer;Bernard A. Rosner;C. Hennekens;M. Stampfer
打鼾是否会增加高血压的风险仍不清楚。作者在1986年对73，231名年龄在40-65岁之间的美国女性护士进行了研究，这些女性护士没有被诊断出心血管疾病或癌症。血压水平和医生诊断的高血压是通过有效的问卷自我报告的。在8年的随访中，报告了7，622例医生诊断的高血压事件。年龄大、吸烟、体重指数、腰围、腰臀比、体重增加、体育活动少和仰卧睡与经常打鼾直接相关。校正年龄、体重指数、腰围和其他协变量后，打鼾与基线时高血压患病率显著升高相关（偶尔打鼾的比值比= 1.22，95%置信区间（CI）：1.16，1.27;经常打鼾的比值比= 1.43，95% CI：1.33，1.5）。在前瞻性分析中，使用高血压事件病例作为结局，高血压的多变量相对风险为1.29（95%CI：1.22，1.37）偶尔打鼾和1.55（95%CI：1.42，1.70）经常打鼾。此外，打鼾与显著较高的收缩压和舒张压水平有关。这些数据表明，打鼾可能会增加女性患高血压的风险，与年龄、体重指数、腰围和其他生活方式因素无关。
Whether snoring increases the risk of hypertension remains unclear. The authors examined the association between snoring and risk of hypertension in a cohort of 73,231 US female nurses aged 40-65 years and without diagnosed cardiovascular disease or cancer in 1986. Blood pressure levels and physician-diagnosed hypertension were self-reported through validated questionnaires. During 8 years of follow-up, 7,622 incident cases of physician-diagnosed hypertension were reported. Older age, smoking, body mass index, waist circumference, waist-hip ratio, weight gain, less physical activity, and sleeping on the back were directly associated with regular snoring. After adjustment for age, body mass index, waist circumference, and other covariates, snoring was associated with a significantly higher prevalence of hypertension at baseline (odds ratio = 1.22, 95% confidence interval (CI): 1.16, 1.27 for occasional snoring and odds ratio = 1.43, 95% CI: 1.33, 1.5 for regular snoring). In prospective analyses using incident cases of hypertension as the outcome, the multivariate relative risks of hypertension were 1.29 (95% CI: 1.22, 1.37) for occasional snoring and 1.55 (95% CI: 1.42, 1.70) for regular snoring. In addition, snoring was associated with significantly higher systolic and diastolic blood pressure levels. These data suggest that snoring may increase risk of hypertension in women, independent of age, body mass index, waist circumference, and other lifestyle factors.