Evaluation of the epidemiologic utility of secondary typing methods for differentiation of Mycobacterium tuberculosis isolates
Evaluation of the epidemiologic utility of secondary typing methods for differentiation of Mycobacterium tuberculosis isolates
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DOI：
10.1128/jcm.41.6.2683-2685.2003
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发表时间：
2003-06-01
影响因子：
9.4
通讯作者：
Crawford, JT
中科院分区：
文献类型：
--
作者：
Kwara, A;Schiro, R;Crawford, JT
评估了Spoligotyping和分枝杆菌散布重复单位可变数目串联重复序列分析（MIRU-VNTR）区分64株结核分枝杆菌分离株和10个IS 6110定义的簇的能力。MIRU-VNTR在减少成簇分离株的数量和簇的大小方面略优于spoligotyping。所有流行病学相关的分离株仍然聚类MIRU-VNTR，但不是spoligotyping。
Spoligotyping and mycobacterial interspersed repetitive unit-variable-number tandem repeat analysis (MIRU-VNTR) were evaluated for the ability to differentiate 64 Mycobacterium tuberculosis isolates from 10 IS6110-defined clusters. MIRU-VNTR performed slightly better than spoligotyping in reducing the number of clustered isolates and the sizes of the clusters. All epidemiologically related isolates remained clustered by MIRU-VNTR but not by spoligotyping.