The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance
The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance
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DOI：
10.3109/00365513.2010.547947
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发表时间：
2011-04-01
影响因子：
2.1
通讯作者：
Ferns, Gordon
中科院分区：
文献类型：
--
作者：
Borai, Anwar;Livingstone, Callum;Ferns, Gordon
的目标。本研究旨在评估HbA1c与胰岛素抵抗之间的相关性，通过各种不同的指标来测量受试者的血糖谱。方法。研究对象为糖耐量正常（NGT, n = 24）、空腹血糖受损（IFG, n = 12）、糖耐量受损（IGT, n = 12）和2型糖尿病（DM, n = 13）。所有患者均在第一次就诊时接受标准口服葡萄糖耐量试验，并在第二次就诊时通过频繁采样的静脉葡萄糖耐量试验确定胰岛素敏感性参数（Si）。结果。与IFG组相比，NGT组HbA1c与Si的相关性更强（r = - 0.65）。与其他胰岛素抵抗指标相比，HbA1c在NGT和2型糖尿病患者之间的重叠最小（0.0%）。结论。对于胰岛素敏感性较高的NGT成人，HbA1c可作为一种简单可靠的胰岛素抵抗指标。
Aim. This study aimed to assess the correlation between HbA1c and insulin resistance as measured by a variety of different indices in subjects from across the glycaemic spectrum. Methods. Subjects with normal glucose tolerance (NGT; n = 24), impaired fasting glucose (IFG; n = 12), impaired glucose tolerance (IGT; n = 12), and type 2 diabetes (DM; n = 13) were studied. All had specimens taken in the context of a standard oral glucose tolerance test at their first visit and had the insulin sensitivity parameter (Si) determined by frequently-sampled intravenous glucose tolerance test at a second visit. Results. HbA1c was more strongly associated with Si in NGT (r = - 0.65) than in IFG (r = - 0.48). Compared to other indices of insulin resistance HbA1c has minimal overlap in values (0.0%) between NGT and subjects with type 2 diabetes. Conclusions. HbA1c can be used as a simple and reliable marker of insulin resistance in NGT adults with relatively high insulin sensitivity.