The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
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发表时间：
2003-11
影响因子：
2
通讯作者：
Yi-Lin Jeng;Mei-Hsuan Wu;Han-Bin Huang;Wei-Yu Lin;S. You;T. Chu;Chien-Jen Chen;Chien‐An Sun
中科院分区：
文献类型：
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作者：
Yi-Lin Jeng;Mei-Hsuan Wu;Han-Bin Huang;Wei-Yu Lin;S. You;T. Chu;Chien-Jen Chen;Chien‐An Sun
在台湾的一项癌症筛查随访研究中，我们进行了一项巢式病例对照研究，以检测MTHFR C677 T基因型与肺癌风险的关系。材料与方法：在1990年7月至2000年12月期间，共招募了59例经组织学证实的肺癌病例和232例无癌对照。MTHFR C677 T基因型通过PCR-限制性片段长度多态性分析确定。结果MTHFR 677 T变异基因型，包括677 CT和677 TT，在39%的病例和47%的对照中观察到。调整后的比值比（OR）为0.71（95%置信区间[CI] = 0.39-1.30）。MTHFR 677 T变异基因型与肺癌风险的负相关在吸烟者和非吸烟者中都是明显的。结论MTHFR 677 T变异基因型可降低肺癌发病风险。需要更大规模的研究，包括膳食叶酸摄入量和变异基因型，以澄清我们的结果。
BACKGROUND We examined the relationship of the MTHFR C677T genotype with the risk of lung cancer in a nested case-control study conducted in a cancer screening follow-up study in Taiwan. MATERIALS AND METHODS A total of 59 histologically confirmed lung cancer cases and 232 cancer-free controls were recruited between July 1990 and December 2000. The MTHFR C677T genotype was determined by a PCR-restriction fragment length polymorphism assay. RESULTS The MTHFR 677T variant genotype, including 677CT and 677TT, was observed in 39% of cases and 47% of controls. The resultant adjusted odds ratio (OR) was 0.71 (95% confidence interval [CI] = 0.39-1.30). The inverse association of the MTHFR 677T variant genotype with lung cancer risk was apparent in both smokers and nonsmokers. CONCLUSION These results suggest that the MTHFR 677T variant genotype reduces the risk of lung cancer. Larger studies incorporating dietary folate intake and the variant genotypes are needed to clarify our results.