The effects of antioxidants on ocular blood flow in patients with glaucoma
The effects of antioxidants on ocular blood flow in patients with glaucoma
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DOI：
10.1111/aos.13530
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发表时间：
2018-03-01
影响因子：
3.4
通讯作者：
Siesky, Brent
中科院分区：
文献类型：
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作者：
Harris, Alon;Gross, Josh;Siesky, Brent
PurposeTo调查的影响，包括银杏抗氧化剂的膳食补充剂，对视网膜和球后血流在患者开角型青光眼（OAG）。MethodsForty 5例确诊OAG患者被纳入一项随机，双盲，安慰剂对照的交叉研究。在抗氧化剂营养品和安慰剂给药前和给药后1个月，对基线和给药后的眼内压（IOP）、眼灌注压（IOP）、球后血流量和视网膜毛细血管血流量进行非侵入性测量（分别为超声和激光多普勒模式）。使用配对t检验评估活性补充剂和安慰剂组之间测量值的变化，p
PurposeTo investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG).MethodsForty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration. Changes in measurements between the active supplement and placebo arms were evaluated using paired t-tests, with p