IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.
IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.
复制标题
IL-15Rα 缺乏导致快速小鼠肌肉中线粒体和肌纤维的差异。
DOI：
10.1016/j.cyto.2012.09.025
复制
发表时间：
2013
期刊：
影响因子：
3.8
通讯作者：
Stauber,WilliamT
中科院分区：
文献类型：
--
作者：
Pistilli,EmidioE;Guo,Ge;Stauber,WilliamT
本研究的目的是测定白细胞介素15受体α基因敲除(IL-15RαKO)小鼠快肌线粒体的变化。我们测试了这样的假设，即IL-15RαKO小鼠的快速肌肉与对照小鼠的肌肉相比，具有更高的线粒体密度和内部结构改变。在IL-15RαKO小鼠的快速肌肉中，线粒体密度增加了48%，线粒体DNA含量也相应增加。虽然分离的线粒体的相对大小没有差异，但IL-15RαKO小鼠的线粒体内部复杂性较低。这些数据支持线粒体生物发生的增加，并提供了缺乏IL-15Rα的EDL肌肉中线粒体密度增加和内部结构改变的直接证据。
The purpose of this study was to determine mitochondrial changes in fast muscles from interleukin-15 receptor alpha knockout (IL-15RαKO) mice. We tested the hypothesis that fast muscles from IL-15RαKO mice would have a greater mitochondrial density and altered internal structure compared to muscles from control mice. In fast muscles from IL-15RαKO mice, mitochondrial density was 48% greater with a corresponding increase in mitochondrial DNA content. Although there were no differences in the relative size of isolated mitochondria, internal complexity was lower in mitochondria from IL-15RαKO mice. These data support an increase in mitochondrial biogenesis and provide direct evidence for a greater density and altered internal structure of mitochondria in EDL muscles deficient in IL-15Rα.