IMPROVED PROCEDURES FOR PREPARATION OF 4-HYDROXY- AND 2-AMINO-4-METHOXY-2-AMINOPYRIDINES
IMPROVED PROCEDURES FOR PREPARATION OF 4-HYDROXY- AND 2-AMINO-4-METHOXY-2-AMINOPYRIDINES
复制标题
4-羟基-和2-氨基-4-甲氧基-2-氨基吡啶的改进制备方法
DOI：
10.1080/00304949709355174
复制
发表时间：
1997
影响因子：
1.5
通讯作者：
Songchun Jiang
中科院分区：
文献类型：
--
作者：
R. Sundberg;Songchun Jiang
据推测，添加溴化钠或碘化钠可能会促进反应。表1中给出的甲酯3的产率证明了这一点。在加入催化量(10mol%)的溴化钠后，反应时间从10天急剧减少到不到1天(条目1)。将溴化钠的用量增加到两个当量，使反应在4小时内完成(条目2)。有趣的是，没有溴1997由有机制剂和程序公司。
It was reasoned that the addition of sodium bromide or sodium iodide might facilitate the reaction. This proved to be the case as indicated by yields of the methyl ester 3 given in Table 1. Upon the addition of a catalytic amount (10 mol%) of sodium bromide, the reaction time decreased dramatically from 10 days to less than one day (Entry 1). Increasing the amount of sodium bromide to two equivalents resulted in the reaction being complete in 4 hours (Entry 2). Interestingly, no bromo1997 by Organic Preparations and Procedures Inc.