Prospective ECG-gated mouse cardiac imaging with a 34-MHz annular array transducer.
Prospective ECG-gated mouse cardiac imaging with a 34-MHz annular array transducer.
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DOI：
10.1109/tuffc.2009.1195
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Aristizábal O
中科院分区：
文献类型：
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作者：
Ketterling JA;Aristizábal O
具有心电图（ECG）和呼吸门控的前瞻性成像提出了一种成像应用，其利用高频（> 20 MHz）环形阵列的改善的图像质量，而不需要快速机械运动。前瞻性成像的局限性在于被成像的对象必须具有周期性稳定的运动。本研究调查了34 MHz环形阵列扫描系统的前瞻性成像的实现，以便以高有效帧速率（> 200帧/秒，fps）对小鼠心脏进行成像。使用ECG和呼吸门控在一系列空间位置采集所有发射-接收对的M模式数据，然后在后处理中综合聚焦数据。M模式数据的脉冲重复频率确定最终B模式图像序列的有效帧速率。对成年小鼠的心脏进行前瞻性成像，并与商业超声生物显微镜（UBM）获得的回顾性数据进行比较。环形阵列数据以500 fps的有效帧速率采集，跨度为0.5 s，UBM数据以1000 fps采集，跨度为0.15 s。所得图像显示，使用前瞻性成像可以清楚地分辨多个心动周期，并且与固定聚焦成像和UBM机器的回顾性成像相比，合成聚焦改善了右心室、室间隔、左心室（LV）后缘和LV乳头肌的图像分辨率和SNR。
Prospective imaging with electrocardiogram (ECG) and respiratory gating presents an imaging application that leverages the improved image quality of high-frequency (> 20 MHz) annular arrays without the need for rapid mechanical motion. The limitation of prospective imaging is that the object being imaged must have a periodically stable motion. The present study investigated the implementation of prospective imaging with a 34-MHz annular-array scan system in order to image the mouse heart at high effective frame rates (> 200 frames/s, fps). M-mode data for all transmit-to-receive pairs were acquired at a series of spatial locations using ECG and respiratory gating and the data were then synthetically focused in post-processing. The pulse-repetition frequency of the M-mode data determined the effective frame rate of the final B-mode image sequence. The hearts of adult mice were prospectively imaged and compared to retrospective data acquired with a commercial ultrasonic biomicroscope (UBM). The annular-array data were acquired at an effective frame rate of 500 fps spanning 0.5 s and the UBM data were acquired at 1000 fps spanning 0.15 s. The resulting images showed that multiple heart cycles could be clearly resolved using prospective imaging and that synthetic focusing improved image resolution and SNR of the right ventricle, interventricular septum, posterior edge of the left ventricle (LV), and papillary muscles of the LV versus fixed-focused imaging and the retrospective imaging of the UBM machine.