Phytoestrogens regulate vitamin D metabolism in the mouse colon:: Relevance for colon tumor prevention and therapy
Phytoestrogens regulate vitamin D metabolism in the mouse colon:: Relevance for colon tumor prevention and therapy
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DOI：
10.1093/jn/132.11.3490s
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发表时间：
2002-11-01
影响因子：
4.2
通讯作者：
Cross, HS
中科院分区：
文献类型：
--
作者：
Kállay, E;Adlercreutz, H;Cross, HS
大豆制品在传统的亚洲饮食中占有很高的比例。大豆蛋白质的主要成分是植物雌激素，如大豆酮。它们可能是导致前列腺和乳腺肿瘤发病率极低的原因，也可能是中国和日本等国家结肠癌发病率极低的原因。血清1，25-二羟维生素D-3水平与某些癌症的发病率呈负相关。通过皮肤暴露于紫外线或在较小程度上营养摄取以及随后通过肝脏和肾脏中的细胞色素P450羟化酶CYP 27 A1、CYP 27 B1（负责合成）和CYP 24（负责催化）将前体维生素D转化为活性激素来确定水平。然而，维生素D的合成也存在于结肠细胞中，并且在早期恶性肿瘤期间得到增强。这可能表明这种分化诱导激素在防御进展中的自分泌/旁分泌作用。我们能够证明，无论是一个单一的大剂量的染料木黄酮或喂养大豆蛋白4个月升高CYP 27 B1和降低CYP 24在小鼠结肠的表达。因此，我们的数据表明，大豆制品消费与结肠肿瘤发病率的负相关性可能是由于结肠合成的抗有丝分裂激素1，25-二羟维生素D-3增强。
Soybean products are highly represented in the traditional Asian diet. Major components of soy proteins are phytoestrogens, such as isoflavones. They may be responsible for the extremely low incidence of prostate and mammary tumors and possibly also of colon cancer in countries such as China and Japan. Serum 1,25-dihydroxyvitamin D-3 level is inversely related to incidence of some cancers. Levels are determined by skin exposure to ultraviolet light or, to a minor extent, nutritional uptake and by subsequent conversion of the precursor vitamin D to the active hormone by the cytochrome P450 hydroxylases CYP27A1, CYP27B1 (responsible for synthesis) and CYP24 (responsible for catabolism) in liver and kidney. However, vitamin D synthesis is also found in colonocytes and is enhanced during incipient malignancy. This may indicate an autocrine/paracrine role for this differentiation-inducing hormone in defense against progression. We were able to demonstrate that either a single large oral dose of genistein or feeding soy protein for 4 mo elevated CYP27B1 and decreased CYP24 expression in the mouse colon. Our data therefore suggest that an inverse correlation of soy product consumption with colon tumor incidence may be consequent to enhanced colonic synthesis of the antimitotic hormone 1,25-dihydroxyvitamin D-3.