ADMINISTRATION OF ANTI-TNF ANTIBODY IMPROVES LEFT-VENTRICULAR FUNCTION IN SEPTIC SHOCK PATIENTS - RESULTS OF A PILOT-STUDY
ADMINISTRATION OF ANTI-TNF ANTIBODY IMPROVES LEFT-VENTRICULAR FUNCTION IN SEPTIC SHOCK PATIENTS - RESULTS OF A PILOT-STUDY
复制标题
DOI：
10.1378/chest.101.3.810
复制
发表时间：
1992-03-01
期刊：
影响因子：
9.6
通讯作者：
DUPONT, E
中科院分区：
文献类型：
--
作者：
VINCENT, JL;BAKKER, J;DUPONT, E
在这项初步研究中，鼠单克隆抗TNF抗体（2 mg/kg）给予10例感染性休克24小时内持续后，静脉输液和肾上腺素能药物初步复苏的患者。这种治疗导致心率降低（4小时时从122 +/- 10至113 +/- 10次/分钟，p < 0.01）与LVSWI增加相关（在2小时从26.5 +/- 5.6至31.5 +/- 10.5 g.m2，p < 0.05），表明在心脏充盈压没有变化的情况下，心室功能改善。6例患者的动脉氧合同时改善。然而，这些变化似乎是短暂的。抗TNF抗体给药后患者心脏功能的改善与最近的实验研究一致，这些研究表明TNF在以感染性休克为特征的心肌抑制中的作用。
In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute at 4 h, p < 0.01) associated with an increase in LVSWI (from 26.5 +/- 5.6 to 31.5 +/- 10.5 g.m2 at 2 h, p < 0.05), indicating in the absence of change in cardiac filling pressures, an improvement in ventricular function. Arterial oxygenation improved concurrently in six patients. These changes, however, appeared transient. The improvement in cardiac function following anti-TNF anti-body administration in patients is in keeping with recent experimental studies indicating the role of TNF in the myocardial depression characterizing septic shock.