Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth
Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth
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DOI：
10.1002/pd.5374
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发表时间：
2018-12-01
影响因子：
3
通讯作者：
Paquette, Lisa
中科院分区：
文献类型：
--
作者：
Rajagopalan, Vidya;Votava-Smith, Jodie K.;Paquette, Lisa
目的先天性心脏病(CHD)相关神经发育异常早在胎儿发育晚期就有报道。虽然一些研究已经描述了儿童早期CHD神经发育结果的差异，但这些报告经常被出生后因素(如手术结果)混淆。最近的研究集中在比较先天性心脏病胎儿和正常对照组之间的神经学变异。在这项工作中，我们提出了比较不同类型的CHD胎儿在宫内大脑发育的差异，通过分析他们在单心室和双心室心脏解剖的类别下。方法利用胎儿磁共振成像(MRI)的最新进展，对不同脑组织(如皮质板、发育中的白质、脑脊液和小脑)的体积轨迹进行量化。结果我们的研究首次区分了脑室内和轴外脑脊液，从而使我们能够更好地识别胎儿大脑成分的变化。结论总体而言，我们的研究结果表明，尽管单侧脑室解剖胎儿和双侧脑室解剖胎儿的脑总体积相似，但它们在脑成分上表现出显著的差异。
Objective Anomalous neurological development associated with congenital heart disease (CHD) has been reported as early as third trimester of fetal development. While several studies have characterized variations in CHD neurodevelopmental outcomes in early childhood, these reports are often confounded by postnatal factors such as surgical outcome. Recent studies have focused on the comparing neurological variations between fetuses with CHD and normal controls. In this work, we present a comparison of in utero variations in brain development between fetuses with different types of CHD, by analyzing them under categories of single ventricle versus biventricular cardiac anatomy. Methods Using recent advances in fetal magnetic resonance imaging (MRI), we quantify the volumetric trajectories of various brain tissues (such as cortical plate, developing white matter, cerebrospinal fluid [CSF], and cerebellum). Results Our study is the first to differentiate between intraventricular and extra-axial CSF thereby allowing us to better identify variations in brain composition of the fetuses. Conclusions Overall, our findings show that while total brain volume is similar between fetuses with single and biventricular anatomy, they exhibit statistically significant disparity in brain composition.