Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior
Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior
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DOI：
10.1016/j.euroneuro.2006.08.005
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发表时间：
2007-04-01
影响因子：
5.6
通讯作者：
Robinson, Terry E.
中科院分区：
文献类型：
--
作者：
Ferrario, Carrie R.;Robinson, Terry E.
有人提出，行为敏化背后的一些神经适应可能在成瘾的发展和持续中发挥作用。然而，致敏是否会促进成瘾特异性症状的发展，如药物摄入的增加，尚不清楚。因此，我们研究了安非他明致敏方案预处理对大鼠后续药物摄入增加的影响，这些大鼠有机会自行服用可卡因。安非他明预处理产生了精神运动性敏化，也加速了随后可卡因摄入量的增加。这表明，由于反复服用安非他明而改变的神经回路，以及诱导致敏，可能与那些负责某些成瘾行为发展的神经回路重叠。(c) 2006 Elsevier B.V.和ECNP。版权所有。
It has been proposed that some neuroadaptations that underlie behavioral sensitization may play a role in the development and persistence of addiction. However, whether or not sensitization facilitates the development of symptoms specific to addiction, such as the escalation of drug intake, is not known. We examined, therefore, the effect of pretreatment with a sensitizing regimen of amphetamine on the escalation of subsequent drug intake in rats given the opportunity to self-administer cocaine. Amphetamine pretreatment produced psychomotor sensitization and also accelerated the subsequent escalation of cocaine intake. This suggests that the neural circuits that are altered as a consequence of repeated amphetamine treatment, and the induction of sensitization, may overlap with those responsible for the development of some addiction-like behaviors. (c) 2006 Elsevier B.V. and ECNP. All rights reserved.