Ventral respiratory group bulbospinal inspiratory neurons participate in vestibular-respiratory reflexes.
Ventral respiratory group bulbospinal inspiratory neurons participate in vestibular-respiratory reflexes.
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腹呼吸组球脊髓吸气神经元参与前庭呼吸反射。
DOI：
10.1152/jn.1995.73.3.1303
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Yates,BJ
中科院分区：
文献类型：
--
作者：
Miller,AD;Yamaguchi,T;Siniaia,MS;Yates,BJ
1.前庭系统对头部的加速度作出反应，并产生用于各种补偿功能的反射反应。介导前庭呼吸反射的神经元回路在很大程度上是未知的。本研究旨在探讨腹侧呼吸群旁疑区球脊髓吸气神经元在介导这些反射中的可能作用。实验是在去大脑、瘫痪和人工通气的猫身上进行的。2.通过电刺激前庭神经的激活产生了从膈神经记录的显著的双侧反射反应，膈神经供应隔膜。反应可能是复杂的，包括神经放电的减少和/或增加。3.细胞外记录从35 VRG吸气神经元，从上颈脊髓逆行激活。这些神经元中几乎有一半（15/35，43%）对前庭刺激有反应。神经元的反应模式是一致的VRG吸气神经元的前庭反射反应，同时记录从膈神经。4.目前的结果表明，大约一半的VRG球脊髓吸气神经元有助于前庭呼吸反射。这些研究结果是相反，我们最近的神经解剖学和电生理学研究表明，前庭输入的背侧呼吸组（DRG）位于孤束腹外侧核的缺乏。因此，似乎有一个差异，在DRG和VRG的吸气神经元参与前庭呼吸反射。
1. The vestibular system responds to accelerations of the head and produces reflex responses that serve a variety of compensatory functions. The neuronal circuitry that mediates vestibulo-respiratory reflexes is largely unknown. The purpose of the present study was to investigate the possible role of bulbospinal inspiratory neurons located in the para-ambigual region of the ventral respiratory group (VRG) in mediating these reflexes. Experiments were carried out in cats that were decerebrated, paralyzed, and artificially ventilated. 2. Activation of the vestibular nerve by electrical stimulation produced prominent bilateral reflex responses recorded from the phrenic nerve, which supplies the diaphragm. The responses could be complex and consisted of a decrease and/or increase in nerve discharge. 3. Extracellular recordings were made from 35 VRG inspiratory neurons that were antidromically activated from the upper cervical spinal cord. Almost one-half of these neurons (15/35, 43%) responded to vestibular stimulation. The neuronal response patterns were consistent with VRG inspiratory neurons contributing to the vestibular reflex response simultaneously recorded from the phrenic nerve. 4. The present results indicate that approximately one-half of VRG bulbospinal inspiratory neurons contribute to vestibulo-respiratory reflexes. These findings are in contrast to our recent neuroanatomic and electrophysiological studies which revealed a paucity of vestibular inputs to the dorsal respiratory group (DRG) located in the ventrolateral nucleus of the solitary tract. Thus there appears to be a difference between inspiratory neurons in the DRG and VRG in regard to participating in vestibulo-respiratory reflexes.