Calcium sensing receptors as integrators of multiple metabolic signals
Calcium sensing receptors as integrators of multiple metabolic signals
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DOI：
10.1016/j.ceca.2003.10.013
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发表时间：
2004-03-01
期刊：
影响因子：
4
通讯作者：
Zhang, ML
中科院分区：
文献类型：
--
作者：
Breitwieser, GE;Miedlich, SU;Zhang, ML
钙敏感受体对维持机体Ca2+稳态至关重要，将血清Ca2+的微小变化转化为甲状旁腺分泌PTH和肾脏排出Ca2+的变化。钙敏感受体也在许多不直接参与Ca2+稳态的细胞和组织中表达，其中它们的作用不太明确。最近的研究表明，钙敏感受体整合了多种代谢信号，包括多价阳离子，pH值，离子强度，氨基酸和多肽，使CaR独特地能够产生细胞和组织特异性反应，不仅感测Ca2+，但局部代谢环境。未来研究的挑战是在每个不同的生理背景下定义CaR反应性。(C)2003 Elsevier Ltd.保留所有权利。
Calcium sensing receptors are critical to maintenance of organismal Ca2+ homeostasis, translating small changes in serum Ca2+ into changes in PTH secretion by the parathyroid glands and Ca2+ excretion by the kidneys. Calcium sensing receptors are also expressed in many cells and tissues not directly involved in Ca2+ homeostasis where their role(s) are less defined. Recent studies have demonstrated that calcium sensing receptors integrate a variety of metabolic signals, including polyvalent cations, pH, ionic strength, amino acids, and polypeptides, making CaR uniquely capable of generating cell- and tissue-specific responses, sensing not only Ca2+, but the local metabolic environment. The challenge for future studies is to define CaR responsiveness in each varied physiological context. (C) 2003 Elsevier Ltd. All rights reserved.