SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
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DOI：
10.1101/gad.12.5.621
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发表时间：
1998-03-01
影响因子：
10.5
通讯作者：
Zon, LI
中科院分区：
文献类型：
--
作者：
Liao, EC;Paw, BH;Zon, LI
SCL/Tal-1是造血干细胞分化所必需的转录因子。尽管SCL也在内皮和神经前体细胞中表达，但SCL在这些细胞中的功能仍不清楚。在斑马鱼突变体Cloche(DO)中，SCL在造血和血管组织中的表达几乎被取消。相应地，以前的研究表明，DO不能区分血液和血管母细胞。遗传分析表明，DO突变与SCL基因座无关。SCL在DO胚胎中的强制表达挽救了DO的血液和血管缺陷，提示SCL在DO下游发挥作用，指定造血和血管分化。
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (do), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that do fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the do mutation is not linked to the SCL locus. forced expression of SCL in do embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of do to specify hematopoietic and vascular differentiation.