On-resin Cα-functionalization of N -arylglycinyl peptides with boronic acids
On-resin Cα-functionalization of N -arylglycinyl peptides with boronic acids
复制标题
N -芳基甘氨酰肽与硼酸的树脂 Cα 功能化
DOI：
10.1039/d2ob00524g
复制
发表时间：
2022
影响因子：
3.2
通讯作者：
Proulx, Caroline
中科院分区：
文献类型：
--
作者：
Young, Hailey A.;Proulx, Caroline
A late-stage α-C–H functionalization reaction of resin-bound, electron-rich N-aryl peptides with boronic acid nucleophiles under mild conditions is reported. We explore the impact of the N-arylglycinyl peptide structure on reactivity, and present a scope of the optimized reaction where both the peptide sequence and nature of boronic acid derivatives are varied.
