Longitudinal changes in hippocampal volume in the Edinburgh High Risk Study of Schizophrenia
Longitudinal changes in hippocampal volume in the Edinburgh High Risk Study of Schizophrenia
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DOI：
10.1016/j.schres.2014.12.003
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发表时间：
2016-06-01
影响因子：
4.5
通讯作者：
Lawrie, S. M.
中科院分区：
文献类型：
--
作者：
Bois, C.;Levita, L.;Lawrie, S. M.
精神分裂症与疾病发作前可能存在的结构性大脑异常有关。目前尚不清楚这些在多大程度上代表了一般的脆弱性指标或与正在发展的临床状态本身相关。目前还不清楚这种状态或特征的改变是否在任何给定的时间点都很明显，或者它们是否随着时间的推移而进展。为了研究这一点，我们在两个时间点（平均扫描间隔 1.87 年）对一群患有精神分裂症高家族风险的未受影响的年轻个体（基线，n = 142；随访，n = 64）和健康对照（基线，n = 36；随访，n = 18）进行了结构性脑扫描。使用 Freesurfer 提供的纵向管道生成海马体和杏仁核的皮层下重建。高风险队列被细分为在研究期间保持良好的个体（HR[well]，基线，n = 68；随访，n = 30）、短暂和/或部分症状不足以支持正式诊断的个体（HR[symp]，基线，n = 57；随访，n = 26）以及随后根据ICD-10标准发展为精神分裂症的个体（HR[ill]，基线，n = 17；随访，n = 8）。比较了海马体和杏仁核的纵向变化，首先关注高风险个体和对照组之间的总体差异，然后关注高风险群体内的亚组差异。我们发现，与对照组相比，所有高风险个体的发育轨迹都发生了显着改变，随着时间的推移，与高风险个体相比，对照组的海马体积显着增加。我们没有发现根据高风险队列中的临床结果改变纵向轨迹的证据。这些结果表明，海马体积发育轨迹的改变与罹患精神分裂症的一般家族倾向相关，因为这种改变与随后的临床结果无关。 (C) 2014 年由 Elsevier B.V. 出版
Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterations may be evident at any given time-point, or whether they progress over time. To investigate this, structural brain scans were acquired at two time-points (mean scan-interval 1.87 years) in a cohort of young unaffected individuals at high familial risk of schizophrenia (baseline, n = 142; follow-up, n = 64) and healthy controls (baseline, n = 36; follow-up, n = 18). Sub-cortical reconstructions of the hippocampus and amygdala were generated using the longitudinal pipeline available with Freesurfer. The high risk cohort was subdivided into individuals that remained well during the study (HR[well], baseline, n = 68; follow-up, n = 30), transient and/or partial symptoms that were insufficient to support a formal diagnosis (HR[symp], baseline, n = 57; follow-up, n = 26) and individuals that subsequently developed schizophrenia according to ICD-10 criteria (HR[ill], baseline, n = 17; follow-up, n = 8). Longitudinal change in the hippocampus and amygdala was compared, focusing first on overall differences between high-risk individuals and controls and then on sub-group differences within the high-risk cohort. We found a significantly altered developmental trajectory for all high risk individuals compared to controls, with controls showing a significant increase in hippocampal volume over time compared to those at high risk. We did not find evidence of altered longitudinal trajectories based on clinical outcome within the high risk cohort. These results suggest that an altered developmental trajectory of hippocampal volume is associated with a general familial predisposition to develop schizophrenia, as this alteration was not related to subsequent clinical outcome. (C) 2014 Published by Elsevier B.V.