Changes of Peroxisome Proliferator-Activated Receptor-γ on Crushed Rat Sciatic Nerves and Differentiated Primary Schwann Cells
Changes of Peroxisome Proliferator-Activated Receptor-γ on Crushed Rat Sciatic Nerves and Differentiated Primary Schwann Cells
复制标题
DOI：
10.1007/s12031-011-9662-8
复制
发表时间：
2012-06-01
影响因子：
3.1
通讯作者：
Liu, Fan
中科院分区：
文献类型：
--
作者：
Cao, Yi;Wang, Qiuhong;Liu, Fan
过氧化物酶体增殖物激活受体-γ（PPAR-γ）已被发现在细胞增殖中发挥重要作用，但其是否参与雪旺细胞分化尚未得到研究。我们发现在坐骨神经损伤中，PPAR-γ的表达主要在雪旺细胞中减少，在分化的雪旺细胞中表达也增加。此外，内源性配体 15 d-PGJ(2) 激活的 PPAR-gamma 会增加 PPAR-gamma 的表达水平和雪旺细胞分化，并且这种作用可能受到其拮抗剂 GDW9662 的保护。这些结果表明PPAR-γ可以促进雪旺细胞分化，在周围神经损伤和再生中发挥重要作用。
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been found to play an essential role in cell proliferation, but whether it was involved in Schwann cells differentiation has never been studied. We have found in sciatic nerve injury that expression of PPAR-gamma decreases mainly in Schwann cells, and it was also increased in differentiated Schwann cells. Further, activated PPAR-gamma by the endogenous ligand 15 d-PGJ(2) increased expressions of PPAR-gamma level and Schwann cell differentiation, and this effect may be protected by its antagonist GDW9662. These results indicate that PPAR-gamma could promote Schwann cell differentiation, which plays an important role in peripheral nerve injury and regeneration.