The histopathology of ankylosing spondylitis: Are there unifying hypotheses?
The histopathology of ankylosing spondylitis: Are there unifying hypotheses?
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DOI：
10.1097/00000441-199810000-00002
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发表时间：
1998-10-01
影响因子：
3.1
通讯作者：
Poole, AR
中科院分区：
文献类型：
--
作者：
Poole, AR
本文对强直性脊柱炎(AS)的一些基本组织病理学特征进行了研究，如管腔炎症和关节突起的形成。这可能与炎症中转化生长因子的产生有关，转化生长因子可以刺激骨形成，也可能与存在分子的膜的分子组成有关，例如通常在软骨中发现的蛋白多糖聚集素。在AS患者中观察到对这些分子的免疫，并在实验中观察到对aggrecan的免疫，或仅对G1结构域的免疫，这可能会导致脊柱炎。其他组织(眼和动脉血管)的受累可能是由于交叉反应免疫。
This article examines some fundamental features of the histopathology of ankylosing spondylitis (AS) such as inflammation in the entheses and syndesmophyte formation. This may be linked to the generation of transforming growth factor in inflammation, which can stimulate bone formation, and to the molecular composition of entheses where molecules are present, such as the proteoglycan aggrecan, that are normally found in cartilage. Immunity to these molecules is observed in patients with AS and in experimental immunity to aggrecan, or the G1 domain only, which can cause spondylitis. Involvement of other tissues (the eye and arterial vessels) may be due to crossreactive immunity.