COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study.
COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study.
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COVID-19 和神经退行性疾病的风险：孟德尔随机化研究
DOI：
10.1038/s41398-022-02052-3
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发表时间：
2022-07-14
影响因子：
6.8
通讯作者：
Shang, Huifang
中科院分区：
文献类型：
--
作者：
Li, Chunyu;Liu, Jiayan;Lin, Junyu;Shang, Huifang
新出现的证据表明，COVID-19与神经退行性疾病之间存在密切关联。然而，是否存在因果关系和影响方向尚不清楚。为了研究COVID-19在神经退行性疾病风险中的致病作用，我们估计了它们的遗传相关性，然后使用汇总统计的全基因组关联研究对COVID-19的易感性、住院率和严重程度以及阿尔茨海默病（AD）、肌萎缩性侧索硬化症、额颞叶痴呆、路易体痴呆、多发性硬化症、和帕金森病我们发现COVID-19住院与AD之间存在显著的正遗传相关（遗传相关性：0.23,P = 8.36E-07）。同时，COVID-19住院与AD的高风险显著相关（OR: 1.02, 95% CI: 1.01-1.03, P: 1.19E-03）。一致地，COVID-19的易感性（OR: 1.05, 95% CI: 1.01 - 1.09, P: 9.30E-03）和严重程度（OR: 1.01, 95% CI: 1.00-1.02, P: 0.012）名义上与AD的高风险相关。在所有敏感性分析下，结果都是稳健的。这些结果表明，COVID-19可增加AD的风险。未来预防或治疗干预措施的发展应重视这一点，以减轻COVID-19的并发症。
Emerging evidence has suggested a close correlation between COVID-19 and neurodegenerative disorders. However, whether there exists a causal association and the effect direction remains unknown. To examine the causative role of COVID-19 in the risk of neurodegenerative disorders, we estimated their genetic correlation, and then conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of susceptibility, hospitalization, and severity of COVID-19, as well as six major neurodegenerative disorders including Alzheimer’s disease (AD), amyotrophic lateral sclerosis, frontotemporal dementia, Lewy body dementia, multiple sclerosis, and Parkinson’s disease. We identified a significant and positive genetic correlation between hospitalization of COVID-19 and AD (genetic correlation: 0.23, P = 8.36E–07). Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of AD (OR: 1.02, 95% CI: 1.01–1.03, P: 1.19E–03). Consistently, susceptibility (OR: 1.05, 95% CI: 1.01–1.09, P: 9.30E–03) and severity (OR: 1.01, 95% CI: 1.00–1.02, P: 0.012) of COVID-19 were nominally associated with higher risk of AD. The results were robust under all sensitivity analyses. These results demonstrated that COVID-19 could increase the risk of AD. Future development of preventive or therapeutic interventions could attach importance to this to alleviate the complications of COVID-19.
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影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
DOI：
10.1186/s13195-020-00744-w
发表时间：
2020-12-30
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Miners S;Kehoe PG;Love S
通讯作者：
Love S
影响因子：
30.8
作者：
Chia R;Sabir MS;Bandres-Ciga S;Saez-Atienzar S;Reynolds RH;Gustavsson E;Walton RL;Ahmed S;Viollet C;Ding J;Makarious MB;Diez-Fairen M;Portley MK;Shah Z;Abramzon Y;Hernandez DG;Blauwendraat C;Stone DJ;Eicher J;Parkkinen L;Ansorge O;Clark L;Honig LS;Marder K;Lemstra A;St George-Hyslop P;Londos E;Morgan K;Lashley T;Warner TT;Jaunmuktane Z;Galasko D;Santana I;Tienari PJ;Myllykangas L;Oinas M;Cairns NJ;Morris JC;Halliday GM;Van Deerlin VM;Trojanowski JQ;Grassano M;Calvo A;Mora G;Canosa A;Floris G;Bohannan RC;Brett F;Gan-Or Z;Geiger JT;Moore A;May P;Krüger R;Goldstein DS;Lopez G;Tayebi N;Sidransky E;American Genome Center;Norcliffe-Kaufmann L;Palma JA;Kaufmann H;Shakkottai VG;Perkins M;Newell KL;Gasser T;Schulte C;Landi F;Salvi E;Cusi D;Masliah E;Kim RC;Caraway CA;Monuki ES;Brunetti M;Dawson TM;Rosenthal LS;Albert MS;Pletnikova O;Troncoso JC;Flanagan ME;Mao Q;Bigio EH;Rodríguez-Rodríguez E;Infante J;Lage C;González-Aramburu I;Sanchez-Juan P;Ghetti B;Keith J;Black SE;Masellis M;Rogaeva E;Duyckaerts C;Brice A;Lesage S;Xiromerisiou G;Barrett MJ;Tilley BS;Gentleman S;Logroscino G;Serrano GE;Beach TG;McKeith IG;Thomas AJ;Attems J;Morris CM;Palmer L;Love S;Troakes C;Al-Sarraj S;Hodges AK;Aarsland D;Klein G;Kaiser SM;Woltjer R;Pastor P;Bekris LM;Leverenz JB;Besser LM;Kuzma A;Renton AE;Goate A;Bennett DA;Scherzer CR;Morris HR;Ferrari R;Albani D;Pickering-Brown S;Faber K;Kukull WA;Morenas-Rodriguez E;Lleó A;Fortea J;Alcolea D;Clarimon J;Nalls MA;Ferrucci L;Resnick SM;Tanaka T;Foroud TM;Graff-Radford NR;Wszolek ZK;Ferman T;Boeve BF;Hardy JA;Topol EJ;Torkamani A;Singleton AB;Ryten M;Dickson DW;Chiò A;Ross OA;Gibbs JR;Dalgard CL;Traynor BJ;Scholz SW
通讯作者：
Scholz SW
影响因子：
2.9
作者：
Liu QQ;Cheng A;Wang Y;Li H;Hu L;Zhao X;Wang T;He F
通讯作者：
He F
影响因子：
14
作者：
Frontera, Jennifer A.;Boutajangout, Allal;Masurkar, Arjun, V;Betensky, Rebecca A.;Ge, Yulin;Vedvyas, Alok;Debure, Ludovic;Moreira, Andre;Lewis, Ariane;Huang, Joshua;Thawani, Sujata;Balcer, Laura;Galetta, Steven;Wisniewski, Thomas
通讯作者：
Wisniewski, Thomas