ACE gene polymorphism: Ischemic heart disease and longevity in 10150 individuals - A case-referent and retrospective cohort study based on the Copenhagen City Heart Study
ACE gene polymorphism: Ischemic heart disease and longevity in 10150 individuals - A case-referent and retrospective cohort study based on the Copenhagen City Heart Study
复制标题
DOI：
10.1161/01.cir.95.10.2358
复制
发表时间：
1997-05-20
期刊：
影响因子：
37.8
通讯作者：
TybjaergHansen, A
中科院分区：
文献类型：
--
作者：
AgerholmLarsen, B;Nordestgaard, BG;TybjaergHansen, A
背景血管紧张素转换酶（ACE）基因插入-缺失多态性缺失等位基因（D）的纯合性已被认为是心肌梗死的一个潜在危险因素。有一个例外，研究的样本到目前为止已经小和/或种族异质性，大多数研究人员研究了manlines.Methods和结果，我们调查了ACE基因型和心肌梗死之间的关联以及其他表现的缺血性心脏病的女性和男性在一个病例参考研究（n=10 - 150），以及在一个回顾性队列研究（n=7263）。该队列来自种族同质的丹麦人口。病例受试者来自同一地理区域，患有缺血性心脏病。无论D等位基因的相对外显率的假设程度如何，缺血性心脏病、冠状动脉造影严重狭窄或心肌梗死的比值比与1.0没有显着差异（P> 0.05）。在缺血性心脏病的危险因素中，ACE基因型和表型变异之间也没有关联。最后，D等位基因的相对频率在20岁到80岁以上的受试者中没有随年龄的变化而变化。结论在两项大型研究中，一项病例参照研究和一项在种族同质的白色人群中进行的回顾性队列研究，没有证据表明心肌梗死或缺血性心脏的任何其他表现的发展存在统计学显著差异在女性或男性中ACE基因多态性的基因型类别之间的疾病。
Background Homozygosity for the deletion allele (D) of the angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism has been suggested to be a potent risk factor for myocardial infarction. With one exception, the samples studied so far have been small and/or ethnically heterogeneous, and most investigators have studied men only.Methods and Results We investigated the association between ACE genotype and myocardial infarction as well as other manifestations of ischemic heart disease for both women and men in a case-referent study (n=10 150) as well as in a retrospective cohort study (n=7263). The cohort was from the ethnically homogeneous Danish population. Case subjects were from the same geographic area and had ischemic heart disease. Irrespective of the assumed degree of relative penetrance of the D allele, the odds ratios were not significantly different from 1.0 (P>.05) for ischemic heart disease, severe stenosis on coronary angiography, or myocardial infarction. There was also no association between ACE genotype and phenotypic variation in recognized risk factors for ischemic heart disease. Finally, the relative frequency of the D allele did not change as a function of age in subjects aged from 20 to greater than or equal to 80 years.Conclusions In two large studies, a case-referent study and a retrospective cohort study in an ethnically homogeneous white population, there was no evidence for a statistically significant difference in the development of myocardial infarction or any other manifestations of ischemic heart disease between genotype classes of the ACE gene polymorphism in either women or men.