Inhibition of Shiga-like toxins by brefeldin A.
Inhibition of Shiga-like toxins by brefeldin A.
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布雷菲德菌素 A 对志贺样毒素的抑制作用。
DOI：
10.1093/infdis/171.3.721
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Donohue-Rolfe,A
中科院分区：
文献类型：
--
作者：
Donta,ST;Tomicic,TK;Donohue-Rolfe,A
志贺样毒素对组织培养HeLa细胞形态和蛋白质合成能力的影响可以通过抑制某些细胞内高尔基功能的brefeldin A来阻止。Brefeldin A对志贺样毒素与细胞的结合无影响。这些结果证明志贺样毒素在移动到其60S核糖体目标位点之前首先由高尔基体处理。
The effects of Shiga-like toxins on the morphology and protein synthetic capability of HeLa cells in tissue culture could be prevented by brefeldin A, an inhibitor of certain intracellular Golgi functions. Brefeldin A was without effect on the binding of Shiga-like toxin to cells. These results provide evidence that the Shiga-like toxins are first processed by the Golgi before moving to their 60S ribosome target site.