Macula densa control of renin secretion.
Macula densa control of renin secretion.
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致密黄斑控制肾素分泌。
DOI：
10.1159/000173402
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Schnermann,J
中科院分区：
文献类型：
--
作者：
Briggs,JP;Lorenz,JN;Weihprecht,H;Schnermann,J
使用从兔肾脏中分离的管状片段进行灌注的技术来研究肾素分泌的致密斑（MD）控制。当灌注液 NaCl 浓度降低时，发现肾素分泌显着且可逆地增加。这种肾素分泌反应发生在生理浓度范围内，即 80 至 20 mM 之间。即使当总溶质浓度保持恒定时，也可以看到减少的 NaCl 的刺激作用。在该制剂中，氯化钠浓度的降低比氯化钠负荷的下降具有更强的刺激作用。发现袢利尿剂可刺激肾素分泌。当大部分Na被Rb或胆碱取代时，肾素分泌受到抑制，但当Cl被羟乙基磺酸盐或乙酸盐取代时，肾素分泌不受抑制。腺苷 1 受体的激活抑制 MD 刺激的肾素分泌，这种作用可被 A1 拮抗剂阻断。该药物部分阻断了 NaCl 诱导的肾素释放抑制，表明腺苷在 MD 控制肾素分泌中可能发挥作用。
The technique of perfusing isolated tubular segments from rabbit kidneys was used to study macula densa (MD) control of renin secretion. Renin secretion was found to be markedly and reversibly increased when perfusate NaCl concentration was reduced. This response of renin secretion occurred within the physiological concentration range, i.e. between 80 and 20 mM. The stimulatory effect of reduced NaCl was seen even when total solute concentration was kept constant. In this preparation a reduction of NaCl concentration was a stronger stimulus than a fall in NaCl load. Loop diuretics were found to stimulate renin secretion. Suppression of renin secretion was seen when most of the Na was replaced by Rb or choline, but not when Cl was replaced with isethionate or acetate. Activation of adenosine-1-receptors inhibited MD-stimulated renin secretion, an effect that was blocked by an A1-antagonist. This agent partially blocked NaCl-induced inhibition of renin release, suggesting a possible role of adenosine in MD control of renin secretion.