[CircRNA as a new field in human disease research].
[CircRNA as a new field in human disease research].
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DOI：
10.19540/j.cnki.cjcmm.20171106.012
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发表时间：
2018-02-01
期刊：
影响因子：
--
通讯作者：
Wang, Jie
中科院分区：
文献类型：
--
作者：
Gao, Jia-Liang;Chen, Guang;Wang, Jie
环状RNA（circRNA）具有高稳定性、物种间高度保守性和组织特异性等特点，有望成为临床诊断、治疗和预后的新的分子生物标志物和靶向治疗的潜在靶点。中医证候研究不仅包括用传统四诊方法所采集的宏观指标，而且还包含了传统四诊方法所不能获取的微观信息。如何处理中医整体观与微观研究的关系，如何解决证候描述的丰富性与微观研究的准确性之间的矛盾，是中医证候微观研究需要考虑的问题。circRNA作为认识人类疾病的一个新领域，其自身的特点可能为中医证候研究提供一些思路。因此，有必要重视不同疾病同一证候在分子水平上的探索，通过对circRNA的理解，揭示证候的内涵和本质。
For the characteristics of high stability， high conservation between species， and tissue specificity， circular RNA(circRNA) has been expected to become a new molecular biomarker for the clinical diagnosis， treatment and prognosis， and the potential target for targeted therapy. Study on the traditional Chinese medicine(TCM) syndrome includes not only the macro indexes collected by using four traditional methods of diagnosis， but also contains some micro information that can not be achieved by using the four traditional diagnosis methods. The questions such as how to deal with the relationship between the holistic concept of TCM and micro research， and how to solve the contradiction between the fuzziness of syndrome description and the accuracy of microscopic research， need to be considered before the micro research in TCM syndrome. circRNA as a new field of understanding human disease， may provide some ideas for the TCM syndrome research due to its characteristics. Overall， it is necessary to pay attention to explore the molecular level with same syndrome in different diseases and reveal the connotation and essence of syndromes by understanding of circRNA.