Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions
Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions
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DOI：
10.1016/j.dental.2011.02.006
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发表时间：
2011-05-01
期刊：
影响因子：
5
通讯作者：
Zheng, Cunge
中科院分区：
文献类型：
--
作者：
Xie, Dong;Weng, Yiming;Zheng, Cunge
Objective.本研究的目的是使用新合成的含聚季铵盐（PQAS）的多酸配制光固化玻璃离子水门汀，并研究PQAS对形成的水门汀的抗压强度和抗菌活性的影响。材料和方法。功能QAS和他们的建设PQAS的合成，表征和配制成实验高强度水泥。采用抗压强度（CS）和变形链球菌活力评价骨水泥的机械强度和抗菌活性。Fuji II LC骨水泥作为对照。在测试之前，将样品在37 ° C的蒸馏水中调节24小时。研究了取代基链长、QAS负载量、接枝率及老化对CS和S的影响。结果：1.所有含PQAS的骨水泥均显示出显著的抗菌活性，并伴有初始CS降低。QAS的链长、负载量和接枝率对接枝率有显著影响。增加链长、负载量、接枝率可显著提高抗菌活性，但降低初始CS。在相同的取代基链长下，含溴代QAS的骨水泥比含氯代QAS的骨水泥具有更好的抗菌性能，但两者的CS值无统计学差异，这表明我们可以直接使用溴代QAS，而不需要将溴代QAS转化为氯代QAS。实验骨水泥显示出较少的CS减少和较高的抗菌活性比富士II LC。长期老化研究表明，骨水泥可能具有持久的抗菌作用。本研究开发了一种新型抗菌玻璃离子水门汀。在本研究的限制范围内，由于其高机械强度和抗菌功能，实验性骨水泥似乎是一种临床上有吸引力的牙科修复材料。由Elsevier Ltd代表牙科材料学会发布。
Objective. The objective of this study was to use the newly synthesized poly(quaternary ammonium salt) (PQAS)-containing polyacid to formulate the light-curable glass-ionomer cements and study the effect of the PQAS on the compressive strength and antibacterial activity of the formed cements.Materials and methods. The functional QAS and their constructed PQAS were synthesized, characterized and formulated into the experimental high-strength cements. Compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the cements. Fuji II LC cementwas used as control. The specimens were conditioned in distilled water at 37 degrees C for 24h prior to testing. The effects of the substitute chain length, loading as well as grafting ratio of the QAS and aging on CS and S. mutans viability were investigated.Results. All the PQAS-containing cements showed a significant antibacterial activity, accompanying with an initial CS reduction. The effects of the chain length, loading and grafting ratio of the QAS were significant. Increasing chain length, loading, grafting ratio significantly enhanced antibacterial activity but reduced the initial CS. Under the same substitute chain length, the cements containing QAS bromide were found to be more antibacterial than those containing QAS chloride although the CS values of the cements were not statistically different from each other, suggesting that we can use QAS bromide directly without converting bromide to chloride. The experimental cement showed less CS reduction and higher antibacterial activity than Fuji II LC. The long-term aging study suggests that the cements may have a long-lasting antibacterial function.Conclusions. This study developed a novel antibacterial glass-ionomer cement. Within the limitations of this study, it appears that the experimental cement is a clinically attractive dental restorative due to its high mechanical strength and antibacterial function. Published by Elsevier Ltd on behalf of Academy of Dental Materials.